Draisci G, Iadarola M J
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, Bethesda, MD 20892.
Brain Res Mol Brain Res. 1989 Jul;6(1):31-7. doi: 10.1016/0169-328x(89)90025-9.
Peripheral inflammation produces a rapid elevation (within 4 h) in preprodynorphin mRNA in neurons of the dorsal spinal cord and an even more rapid elevation in c-fos proto-oncogene mRNA (within 30 min). During this period a relatively modest increase is also observed in spinal cord preproenkephalin mRNA. Previous anatomical studies have shown that the neurons in which these transcripts increase have overlapping distributions. Assuming that these events occur in the same cells, it suggests the possibility that newly synthesized c-fos protein may participate in transcriptional regulation of opioid genes in spinal cord.
外周炎症会使背侧脊髓神经元中的前强啡肽原mRNA迅速升高（4小时内），并使c-fos原癌基因mRNA升高得更快（30分钟内）。在此期间，脊髓前脑啡肽原mRNA也会出现相对适度的增加。先前的解剖学研究表明，这些转录本增加的神经元具有重叠分布。假设这些事件发生在相同的细胞中，这表明新合成的c-fos蛋白可能参与脊髓中阿片样物质基因转录调控的可能性。
