Rabitti C, Fadda G, Minimo C, Coronetta F, Russo R M, Capelli A
Pathologica. 1989 Mar-Apr;81(1072):171-7.
The Authors emphasize the importance of preoperative aspiration cytology in the diagnosis of 5 medullary types out of 58 thyroid carcinomas observed in the Institute of Pathology of the Università Cattolica del S. Cuore of Rome in the period 1983-88. All the cases were diagnosed preoperatively by mean of a fine-needle aspiration cytological specimen; the case where morphological diagnosis was doubtful were studied with immunohistochemical techniques for calcitonin and CEA. Out of all cases, they report one case of multiple endocrine adenomatosis type II with medullary thyroid carcinoma and pheochromocytoma and another one with cervical node metastases without a clinically detectable thyroid swelling. Therefore, the authors propose the fine-needle aspiration cytology as a simple and important mean in the preoperative diagnostic procedure in case of medullary thyroid carcinoma.
作者强调了术前细针穿刺细胞学检查在诊断罗马天主教圣心大学病理研究所1983 - 1988年间观察到的58例甲状腺癌中的5种髓样类型的重要性。所有病例均通过细针穿刺细胞学标本进行术前诊断；形态学诊断存疑的病例采用降钙素和癌胚抗原免疫组化技术进行研究。在所有病例中，他们报告了1例伴有甲状腺髓样癌和嗜铬细胞瘤的II型多发性内分泌腺瘤病，以及另1例伴有颈部淋巴结转移但临床上未检测到甲状腺肿大的病例。因此，作者提出细针穿刺细胞学检查是甲状腺髓样癌术前诊断程序中一种简单而重要的方法。
