Oh Sumin, Oh Sejong
Department of Nanobiomedical Science, Dankook University, Cheonan 330-714, Korea.
Genomics Inform. 2014 Sep;12(3):127-33. doi: 10.5808/GI.2014.12.3.127. Epub 2014 Sep 30.
Gastritis is a major disease that has the potential to grow as gastric cancer. Gastric cancer is a very common cancer, and it is related to a very high mortality rate in Korea. This disease is known to have various reasons, including infection with Helicobacter pylori, dietary habits, tobacco, and alcohol. The incidence rate of gastritis has reported to differ between age, population, and gender. However, unlike other factors, there has been no analysis based on gender. So, we examined the high risk factors of gastritis in each gender in the Korean population by focusing on sex. We performed an analysis of 120 clinical characteristics and genome-wide association studies (GWAS) using 349,184 single-nucleotide polymorphisms from the results of Anseong and Ansan cohort study in the Korea Association Resource (KARE) project. As the result, we could not prove a strong relation with these factors and gastritis or gastric ulcer in the GWAS. However, we confirmed several already-known risk factors and also found some differences of clinical characteristics in each gender using logistic regression. As a result of the logistic regression, a relation with hyperlipidemia, coronary artery disease, myocardial infarction, hyperlipidemia therapy, hypotensive or antihypotensive drug, diastolic blood pressure, and gastritis was seen in males; the results of this study suggest that vascular disease has a potential association with gastritis in males.
胃炎是一种可能发展为胃癌的主要疾病。胃癌是一种非常常见的癌症，在韩国其死亡率很高。已知这种疾病有多种病因，包括幽门螺杆菌感染、饮食习惯、烟草和酒精。据报道，胃炎的发病率在年龄、人群和性别之间存在差异。然而，与其他因素不同的是，此前尚未有基于性别的分析。因此，我们通过关注性别，研究了韩国人群中不同性别胃炎的高危因素。我们利用韩国协会资源（KARE）项目中安城和安山队列研究的结果，对120项临床特征和349,184个单核苷酸多态性进行了全基因组关联研究（GWAS）分析。结果，我们在GWAS中未能证实这些因素与胃炎或胃溃疡有很强的关联。然而，我们确认了几个已知的危险因素，并通过逻辑回归发现了不同性别在临床特征上的一些差异。逻辑回归结果显示，男性中高脂血症、冠状动脉疾病、心肌梗死、高脂血症治疗、降压或抗降压药物、舒张压与胃炎有关；本研究结果表明，血管疾病在男性中可能与胃炎存在关联。
