Kulesa Paul M, McLennan Rebecca
Stowers Institute for Medical Research 1000 E. 50th St, Kansas City, MO 64110 USA ; Department of Anatomy and Cell Biology, University of Kansas School of Medicine Kansas City, KS, 66160 USA.
Stowers Institute for Medical Research 1000 E. 50th St, Kansas City, MO 64110 USA.
F1000Prime Rep. 2015 Jan 5;7:02. doi: 10.12703/P7-02. eCollection 2015.
Embryonic cell migration patterns are amazingly complex in the timing and spatial distribution of cells throughout the vertebrate landscape. However, advances in in vivo visualization, cell interrogation, and computational modeling are extracting critical features that underlie the mechanistic nature of these patterns. The focus of this review highlights recent advances in the study of the highly invasive neural crest cells and their migratory patterns during embryonic development. We discuss these advances within three major themes and include a description of computational models that have emerged to more rapidly integrate and test hypothetical mechanisms of neural crest migration. We conclude with technological advances that promise to reveal new insights and help translate results to human neural crest-related birth defects and metastatic cancer.
在整个脊椎动物体内，胚胎细胞迁移模式在细胞的时间和空间分布上极其复杂。然而，体内可视化、细胞检测和计算建模方面的进展正在提取这些模式的机械本质所依据的关键特征。本综述的重点突出了在胚胎发育过程中对高度侵袭性的神经嵴细胞及其迁移模式研究的最新进展。我们在三个主要主题下讨论这些进展，并描述已出现的计算模型，这些模型能更快速地整合和测试神经嵴迁移的假设机制。我们以技术进展作为总结，这些进展有望揭示新的见解，并有助于将研究结果转化应用于人类与神经嵴相关的出生缺陷和转移性癌症。
