Ito H, Yokozaki H, Ito M, Tahara E
Department of Pathology, Hiroshima University School of Medicine, Japan.
Arch Pathol Lab Med. 1989 Sep;113(9):1030-4.
A total of 13 gastric papillary adenomas composed of 8 papillary and 5 papillotubular adenomas were examined pathologically and immunohistochemically. They showed a dome-like or pedunculated appearance and were located at the antrum, except for one adenoma. Histologically, the adenoma cells showed atypia in varying degree and focal adenocarcinoma was noted in seven lesions. The number of goblet cells was apparently smaller in the papillary than in the tubular portion. Lysozyme was present at the supranuclear region in most papillary adenoma cells, whereas it was concentrated in Paneth's granules in tubular adenoma cells. No difference was found in the distribution and frequency of carcinoembryonic antigen, secretory component, and carbohydrate antigen CA 19-9 between papillary and tubular adenomas. Paucity of endocrine cells also characterized gastric papillary adenoma. Different phenotypic expressions might reflect the difference in histogenesis between papillary adenoma and tubular adenoma.
对总共13例胃乳头状腺瘤进行了病理和免疫组化检查，其中包括8例乳头状腺瘤和5例乳头管状腺瘤。它们呈圆顶状或有蒂，除1例腺瘤外均位于胃窦部。组织学上，腺瘤细胞呈现不同程度的异型性，7个病灶中发现局灶性腺癌。乳头状部分的杯状细胞数量明显少于管状部分。溶菌酶在大多数乳头状腺瘤细胞的核上区存在，而在管状腺瘤细胞中集中在潘氏颗粒中。乳头状腺瘤和管状腺瘤在癌胚抗原、分泌成分和糖类抗原CA 19-9的分布和频率上未发现差异。内分泌细胞稀少也是胃乳头状腺瘤的特征。不同的表型表达可能反映了乳头状腺瘤和管状腺瘤在组织发生上的差异。
