Ito H, Hata J, Oda N, Miyamori S, Tahara E
Virchows Arch A Pathol Anat Histopathol. 1986;410(3):239-45. doi: 10.1007/BF00710830.
Serotonin was examined immunohistochemically in seven tubular adenomas, 194 adenocarcinomas and 41 endocrine cell tumours of the stomach. In tubular adenomas, serotonin-containing cells showing argentaffinity were present in the lower portion of the adenomatous glands and were considered to be an expression of intestinal character. Scattered serotonin-containing tumour cells were found in 60 (30.9%) of 194 adenocarcinomas regardless of their histological type. Cell fusions between carcinoma and enterochromaffin (EC) cells might be a possible mechanism for the occurrence of serotonin-containing cells within the tumour. In 17 (54.8%) of 31 endocrine cell carcinomas, serotonin-containing tumour cells were observed in a variable degree in contrast to the absence of these cells in classical carcinoid. Moreover, diffuse serotonin reactivity was found in four cases of scirrhous endocrine cell carcinoma. The histogenesis and the occurrence of serotonin-containing cells in each type of gastric tumour is also discussed.
对7例胃管状腺瘤、194例腺癌和41例胃内分泌细胞瘤进行了血清素免疫组织化学检测。在管状腺瘤中，显示嗜银性的含血清素细胞存在于腺瘤性腺体的下部，被认为是肠化生的一种表现。在194例腺癌中，无论其组织学类型如何，60例（30.9%）发现有散在的含血清素肿瘤细胞。癌与肠嗜铬（EC）细胞之间的细胞融合可能是肿瘤内出现含血清素细胞的一种可能机制。在31例内分泌细胞癌中的17例（54.8%）中，观察到不同程度的含血清素肿瘤细胞，而经典类癌中则没有这些细胞。此外，在4例硬癌性内分泌细胞癌中发现弥漫性血清素反应。还讨论了每种类型胃肿瘤中血清素细胞的组织发生和出现情况。
