Pereira Robyn D, De Long Nicole E, Wang Ruijun C, Yazdi Fereshteh T, Holloway Alison C, Raha Sandeep
Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5 ; The Graduate Program in Medical Sciences, McMaster University, 1200 Main Street W., Hamilton, ON, Canada L8N 3Z5.
Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada L8N 3Z5.
Biomed Res Int. 2015;2015:814543. doi: 10.1155/2015/814543. Epub 2015 Jan 29.
Proper placental development and function are central to the health of both the mother and the fetus during pregnancy. A critical component of healthy placental function is the proper development of its vascular network. Poor vascularization of the placenta can lead to fetal growth restriction, preeclampsia, and in some cases fetal death. Therefore, understanding the mechanisms by which uterine stressors influence the development of the placental vasculature and contribute to placental dysfunction is of central importance to ensuring a healthy pregnancy. In this review we discuss how oxidative stress observed in maternal smoking, maternal obesity, and preeclampsia has been associated with aberrant angiogenesis and placental dysfunction resulting in adverse pregnancy outcomes. We also highlight that oxidative stress can influence the expression of a number of transcription factors important in mediating angiogenesis. Therefore, understanding how oxidative stress affects redox-sensitive transcription factors within the placenta may elucidate potential therapeutic targets for correcting abnormal placental angiogenesis and function.
孕期胎盘的正常发育和功能对于母亲和胎儿的健康至关重要。健康胎盘功能的一个关键组成部分是其血管网络的正常发育。胎盘血管形成不良可导致胎儿生长受限、先兆子痫，在某些情况下还会导致胎儿死亡。因此，了解子宫应激源影响胎盘血管系统发育并导致胎盘功能障碍的机制对于确保健康妊娠至关重要。在本综述中，我们讨论了在母亲吸烟、母亲肥胖和先兆子痫中观察到的氧化应激如何与异常血管生成和胎盘功能障碍相关联，从而导致不良妊娠结局。我们还强调，氧化应激可影响许多在介导血管生成中起重要作用的转录因子的表达。因此，了解氧化应激如何影响胎盘内对氧化还原敏感的转录因子，可能会阐明纠正胎盘异常血管生成和功能的潜在治疗靶点。
