Giordano A, Whyte P, Harlow E, Franza B R, Beach D, Draetta G
Cold Spring Harbor Laboratory, New York 11724.
Cell. 1989 Sep 8;58(5):981-90. doi: 10.1016/0092-8674(89)90949-5.
p60 is a cellular protein that binds to the adenovirus E1A protein complex in virally infected or transformed human cells. In both infected and uninfected cells, p60 was found in a complex with the cdc2 protein kinase. Immune complexes containing p60 and cdc2 display a cell cycle-dependent histone H1 kinase activity that is most active in interphase. The previously described cdc2-p62/cyclin complex also acts as a histone H1 kinase but is maximally active in mitotic metaphase. The shift in the timing of activation of different cdc2-containing complexes suggests that each might play a distinct role in regulation of the cell cycle.
p60是一种细胞蛋白，在病毒感染或转化的人类细胞中与腺病毒E1A蛋白复合物结合。在感染和未感染的细胞中，均发现p60与细胞周期蛋白依赖性激酶2（cdc2）形成复合物。含有p60和cdc2的免疫复合物表现出细胞周期依赖性组蛋白H1激酶活性，在间期最为活跃。先前描述的cdc2-p62/细胞周期蛋白复合物也作为组蛋白H1激酶起作用，但在有丝分裂中期活性最高。不同的含cdc2复合物激活时间的变化表明，每种复合物可能在细胞周期调控中发挥不同的作用。
