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[百日咳疫苗。疾病的再度出现及新的疫苗接种策略]

[Pertussis vaccine. Reemergence of the disease and new vaccination strategies].

作者信息

Moraga-Llop Fernando A, Campins-Martí Magda

机构信息

Societat Catalana de Pediatria, Asociación Española de Vacunología, Barcelona, España.

Servicio de Medicina Preventiva y Epidemiología, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

出版信息

Enferm Infecc Microbiol Clin. 2015 Mar;33(3):190-6. doi: 10.1016/j.eimc.2015.02.001. Epub 2015 Feb 20.

Abstract

Pertussis continues to be a public health problem despite the significant decrease in its incidence due to routine vaccination. Resurgence of the disease in countries that have maintained high vaccination coverage has been observed in recent years. Although vaccination is the most effective preventive control measure, both natural and artificial immunity wane over time, and thus the protection offered by current vaccines is not long-lasting. Furthermore, acellular vaccines are less effective. The implementation of new vaccine strategies is required. Vaccination of pregnant women is the most effective strategy for preventing pertussis in young infants, who are the most vulnerable, and should be recommended together with cocooning, ie vaccination of future household and extra-domiciliary contacts who are the main transmitters of the disease.

摘要

尽管常规疫苗接种使百日咳发病率显著下降,但它仍然是一个公共卫生问题。近年来,在疫苗接种覆盖率一直很高的国家中,该病出现了复发。虽然疫苗接种是最有效的预防控制措施,但自然免疫和人工免疫都会随着时间的推移而减弱,因此目前疫苗提供的保护并非持久。此外,无细胞疫苗效果较差。需要实施新的疫苗策略。孕妇接种疫苗是预防最易感染的幼儿百日咳的最有效策略,应与“茧式保护”一起推荐,即对未来家庭和户外接触者进行疫苗接种,这些人是该病的主要传播者。

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