Agrawal Ashish, Singh Sanjeev, Kolhapure Shafi, Kandeil Walid, Pai Rishma, Singhal Tanu
Medical Affairs Department, GSK, Mumbai, India.
R&D Department, GSK, Wavre, Belgium.
Infect Dis Ther. 2019 Jun;8(2):139-153. doi: 10.1007/s40121-019-0245-2. Epub 2019 May 3.
Pertussis is an under-recognized cause of neonatal morbidity and mortality. To review information on the epidemiology and disease burden of neonatal pertussis in South and Southeast Asian countries, a systematic literature review of three bibliographic databases was undertaken. Peer-reviewed original studies on neonatal pertussis epidemiology and burden published since 2000, with a geographical scope limited to South and Southeast Asian countries, were included. Data were systematically extracted based on parameters defined a priori. Our findings show that the burden of neonatal pertussis and its complications is substantial. An increase in the number of pertussis cases has been noted since early 2000, ranging from 61 to 92.9% in infants 0-3 months old. The most common symptoms an infant is likely to present with are cough with or without paroxysms, cyanosis, apnea, tachypnea, difficulty in breathing and leukocytosis. In addition, it can lead to hospitalization (length of stay: 5-7 days), complications (e.g., pneumonia, seizures) and mortality ranging from 5.6 to 14.7%. Other observations indicate that diagnosis is challenging because of non-specific clinical symptoms. Specifically, for obstetricians and gynecologists, the information available for making informed decisions on the prevention of neonatal pertussis is unreliable. Maternal immunization against pertussis during late stages of pregnancy has proven to be efficacious and well tolerated. A high burden of neonatal pertussis, as well as its complications, is observed in South and Southeast Asian countries. There is a need to intensify efforts to protect this vulnerable population with maternal vaccination.Funding: GlaxoSmithKline Biologicals SAPlain Language Summary: Plain language summary available for this article. Please see Fig. 1 and the following link: https://doi.org/10.6084/m9.figshare.7951187 .
百日咳是新生儿发病和死亡的一个未得到充分认识的原因。为了回顾南亚和东南亚国家新生儿百日咳的流行病学和疾病负担信息，我们对三个文献数据库进行了系统的文献综述。纳入了自2000年以来发表的、地理范围限于南亚和东南亚国家的关于新生儿百日咳流行病学和负担的同行评审原创研究。根据预先定义的参数系统地提取数据。我们的研究结果表明，新生儿百日咳及其并发症的负担相当大。自2000年初以来，百日咳病例数有所增加，0至3个月大的婴儿中增加幅度在61%至92.9%之间。婴儿最常见的症状可能是伴有或不伴有阵发性咳嗽、发绀、呼吸暂停、呼吸急促、呼吸困难和白细胞增多。此外，它可导致住院（住院时间：5至7天）、并发症（如肺炎、癫痫发作）以及死亡率在5.6%至14.7%之间。其他观察结果表明，由于临床症状不具特异性，诊断具有挑战性。具体而言，对于产科医生和妇科医生来说，用于就预防新生儿百日咳做出明智决策的现有信息并不可靠。在妊娠晚期进行孕产妇百日咳免疫已被证明是有效的且耐受性良好。在南亚和东南亚国家观察到新生儿百日咳及其并发症的负担很高。需要加大力度通过孕产妇疫苗接种来保护这一脆弱人群。资助：葛兰素史克生物制品公司。简明语言摘要：本文有简明语言摘要。请见图1及以下链接：https://doi.org/10.6084/m9.figshare.7951187 。
