Park Young-Woo, Kang Byung-Jae, Lim Jae Hyun, Ahn Jung-Mo, Lim Hyun Sook
Daegu Animal Medical Center, 36, Dongdaegu-ro, Suseong-gu, Daegu, 706-842, Korea.
Incheon Technopark Bio Center, 12, Gaetbeol-ro, Yeonsu-gu, Incheon, 406-740, Korea.
Vet Ophthalmol. 2015 Nov;18(6):521-6. doi: 10.1111/vop.12263. Epub 2015 Feb 24.
A 13-year-old castrated male Yorkshire terrier developed a corneal ulcer 2 weeks after intracapsular lens extraction (ICLE) in the right eye. The corneal ulcer was treated with levofloxacin eye drops. A plaque with a white luster developed in the central cornea 2 weeks after treatment with levofloxacin eye drops. The corneal plaque was surgically removed under inhalant anesthesia. The corneal plaque displayed antimicrobial activity against Escherichia coli. Furthermore, levofloxacin content in the plaque was confirmed by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) mass spectrometry (MS). The corneal ulcer completely resolved 2 weeks after the surgical removal of the corneal lesion and replacement of levofloxacin eye drops with tobramycin eye drops. Although the topical use of levofloxacin is unlikely to lead to corneal chemical deposits due to the high water solubility of the drug compared to other topical fluoroquinolones, this patient developed corneal plaque of the antibiotic drop.
一只13岁去势的雄性约克夏梗犬在右眼囊内晶状体摘除术（ICLE）后2周出现角膜溃疡。角膜溃疡用左氧氟沙星滴眼液治疗。使用左氧氟沙星滴眼液治疗2周后，中央角膜出现一个有白色光泽的斑块。在吸入麻醉下手术切除角膜斑块。该角膜斑块对大肠杆菌显示出抗菌活性。此外，通过基质辅助激光解吸/电离飞行时间/飞行时间（MALDI-TOF/TOF）质谱（MS）证实了斑块中的左氧氟沙星含量。手术切除角膜病变并用妥布霉素滴眼液替代左氧氟沙星滴眼液2周后，角膜溃疡完全愈合。尽管与其他局部用氟喹诺酮类药物相比，左氧氟沙星因具有高水溶性，局部使用不太可能导致角膜化学沉积物，但该患者出现了抗生素滴眼液引起的角膜斑块。
