Morilla Maria Jose, Romero Eder Lilia
Programa de Nanomedicinas, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 352, Bernal B1876BXD, Buenos Aires, Argentina.
Nanomedicine (Lond). 2015 Feb;10(3):465-81. doi: 10.2217/nnm.14.185.
Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi. After a mostly clinically silent acute phase, the disease becomes a lifelong chronic condition that can lead to chronic heart failure and thromboembolic phenomena followed by sudden death. Antichagasic treatment is only effective in the acute phase but fails to eradicate the intracellular form of parasites and causes severe toxicity in adults. Although conventional oral benznidazol is not a safe and efficient drug to cure chronic adult patients, current preclinical data is insufficient to envisage if conventional antichagasic treatment could be realistically improved by a nanomedical approach. This review will discuss how nanomedicines could help to improve the performance of therapeutics, vaccines and diagnosis of Chagas disease.
恰加斯病是一种由原生动物克氏锥虫引起的被忽视的寄生虫感染。在大多为临床无症状的急性期过后，该疾病会成为一种终身慢性疾病，可导致慢性心力衰竭和血栓栓塞现象，进而引发猝死。抗恰加斯病治疗仅在急性期有效，但无法根除细胞内形式的寄生虫，且在成人中会引起严重毒性。尽管传统口服苯硝唑并非治愈成年慢性患者的安全有效药物，但目前的临床前数据不足以设想纳米医学方法是否能切实改善传统抗恰加斯病治疗。本综述将讨论纳米药物如何有助于提高恰加斯病治疗、疫苗和诊断的性能。
