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人血清和肝脏中芳基酯酶的特性与行为

Characteristics and behaviour of arylesterase in human serum and liver.

作者信息

Burlina A, Michielin E, Galzigna L

出版信息

Eur J Clin Invest. 1977 Feb;7(1):17-20. doi: 10.1111/j.1365-2362.1977.tb01564.x.

DOI:10.1111/j.1365-2362.1977.tb01564.x
PMID:402272
Abstract

Human arylesterase is localized in liver microsomes where the presence of different electrophoretic bands corresponding to the serum bands can be recognized. Serum arylesterase is mainly a result of liver activity and its high level might be explained by a low rate of elimination in urine. The behaviour of arylesterase towards inhibitors shows certain similarities to that of some of the proteases, such as trypsin. The clinical value of serum arylesterase determination in assessing liver function is confirmed by its isoenzyme behaviour in cirrhosis and porto-caval shunt.

摘要

人芳基酯酶定位于肝微粒体中,在那里可以识别出与血清条带相对应的不同电泳条带。血清芳基酯酶主要是肝脏活动的结果,其高水平可能是由于尿中排泄率低所致。芳基酯酶对抑制剂的反应与某些蛋白酶(如胰蛋白酶)有一定相似性。血清芳基酯酶测定在评估肝功能方面的临床价值通过其在肝硬化和门腔分流中的同工酶表现得到证实。

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