Zhang Licheng, Lv Houchen, Zheng Hailiang, Li Ming, Yin Pengbin, Peng Ye, Gao Yuan, Zhang Lihai, Tang Peifu
Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China.
Department of Bioengineering, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
PLoS One. 2015 Dec 28;10(12):e0145879. doi: 10.1371/journal.pone.0145879. eCollection 2015.
Calcaneal quantitative ultrasound (QUS), which is used in the evaluation of osteoporosis, is believed to be intimately associated with the characteristics of the proximal femur. However, the specific associations of calcaneal QUS with characteristics of the hip sub-regions remain unclear.
A cross-sectional assessment of 53 osteoporotic patients was performed for the skeletal status of the heel and hip.
We prospectively enrolled 53 female osteoporotic patients with femoral fractures. Calcaneal QUS, dual energy X-ray absorptiometry (DXA), and hip structural analysis (HSA) were performed for each patient. Femoral heads were obtained during the surgery, and principal compressive trabeculae (PCT) were extracted by a three-dimensional printing technique-assisted method. Pearson's correlation between QUS measurement with DXA, HSA-derived parameters and Young's modulus were calculated in order to evaluate the specific association of QUS with the parameters for the hip sub-regions, including the femoral neck, trochanteric and Ward's areas, and the femoral shaft, respectively.
Significant correlations were found between estimated BMD (Est.BMD) and BMD of different sub-regions of proximal femur. However, the correlation coefficient of trochanteric area (r = 0.356, p = 0.009) was higher than that of the neck area (r = 0.297, p = 0.031) and total proximal femur (r = 0.291, p = 0.034). Furthermore, the quantitative ultrasound index (QUI) was significantly correlated with the HSA-derived parameters of the trochanteric area (r value: 0.315-0.356, all p<0.05) as well as with the Young's modulus of PCT from the femoral head (r = 0.589, p<0.001).
The calcaneal bone had an intimate association with the trochanteric cancellous bone. To a certain extent, the parameters of the calcaneal QUS can reflect the characteristics of the trochanteric area of the proximal hip, although not specifically reflective of those of the femoral neck or shaft.
用于评估骨质疏松症的跟骨定量超声（QUS）被认为与股骨近端特征密切相关。然而，跟骨QUS与髋部亚区域特征的具体关联仍不清楚。
对53例骨质疏松症患者的足跟和髋部骨骼状况进行横断面评估。
我们前瞻性纳入了53例股骨骨折的女性骨质疏松症患者。对每位患者进行跟骨QUS、双能X线吸收法（DXA）和髋部结构分析（HSA）。在手术过程中获取股骨头，并通过三维打印技术辅助方法提取主要压缩小梁（PCT）。计算QUS测量值与DXA、HSA衍生参数和杨氏模量之间的Pearson相关性，以评估QUS与髋部亚区域参数（包括股骨颈、转子间和沃德三角区以及股骨干）的具体关联。
估计骨密度（Est.BMD）与股骨近端不同亚区域的骨密度之间存在显著相关性。然而，转子间区域的相关系数（r = 0.356，p = 0.009）高于颈部区域（r = 0.297，p = 0.031）和股骨近端总体（r = 0.291，p = 0.034）。此外，定量超声指数（QUI）与转子间区域的HSA衍生参数显著相关（r值：0.315 - 0.356，所有p < 0.05），以及与股骨头PCT的杨氏模量显著相关（r = 0.589，p < 0.001）。
跟骨与转子间松质骨密切相关。尽管不能具体反映股骨颈或股骨干的特征，但跟骨QUS参数在一定程度上可以反映近端髋部转子间区域的特征。
Zotero 插件
