Kudo Y, Ishida R
Pharmacology Department, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Jpn J Pharmacol. 1989 Aug;50(4):515-9. doi: 10.1254/jjp.50.515.
To clarify the antivertiginous effect of afloqualone, an antispastic drug, we examined its action on the vestibular nervous system in cats. The results suggest that afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site.
为阐明抗痉挛药物阿夫喹酮的抗眩晕作用，我们研究了其对猫前庭神经系统的作用。结果表明，阿夫喹酮可能通过抑制选择性多突触传递以及增强外侧前庭核（LVN）中γ-氨基丁酸（GABA）和甘氨酸的作用来抑制前庭眼震，并且其增强GABA的作用被认为归因于LVN神经元部位GABA受体敏感性的增加。
