Sorge J
Zentrum Anaesthesiologie der Medizinischen Hochschule Hannover.
Klin Padiatr. 1989 Jul-Aug;201(4):333-6. doi: 10.1055/s-2008-1026724.
A high percentage of adults and children with advanced cancer suffer from pain. Strong opioids for pain control, e.g. morphine, slow-released morphine or buprenorphine, should be administered early according to the intensity of pain. The analgesics should be given orally whenever possible. They must be given at fixed intervals based on the duration of their action. The dose must be titrated to the needs of the patient. Sometimes more than 1000 mg morphine orally per day is necessary. Correctly used strong opioids produce only a few side-effects, especially constipation and vomiting. Many studies in adult cancer patients all over the world demonstrate the effectiveness of strong opioids for pain control. Children should be treated in the same way and comparable data in children with cancer pain must be collected.
很大比例的晚期癌症成人和儿童患者遭受疼痛折磨。用于控制疼痛的强效阿片类药物，如吗啡、缓释吗啡或丁丙诺啡，应根据疼痛强度尽早给药。镇痛剂应尽可能口服。必须根据其作用持续时间按固定间隔给药。剂量必须根据患者的需求进行滴定。有时每天口服超过1000毫克吗啡是必要的。正确使用强效阿片类药物只会产生一些副作用，尤其是便秘和呕吐。世界各地许多针对成年癌症患者的研究都证明了强效阿片类药物在控制疼痛方面的有效性。儿童也应接受同样的治疗，并且必须收集有关癌症疼痛儿童的可比数据。
