Burza M, Ginobbi P, Fusco G, Laurenzi L, Tirelli W, Arcuri E
Istituto Regina Elena, Servizio di Terapia del Dolore e Rianimazione, Roma, Italia.
Clin Ter. 1998 Jul-Aug;149(4):277-80.
Fentanyl TTS, the only transdermal opioid, represents a real tool for a better quality of life in patients with cancer pain. In this paper we report a short description of the pharmacologic properties and administration procedures of this drug that is a useful alternative when other opioids recommended on the third step of the WHO analgesic ladder, are ineffective or present unbearable side effects (nausea and/or vomiting-severe mucosites and dysphagia). In particular we indicated some changes and adjustments switching from morphine per os to fentanyl TTS. In addition we report the results of a study carried out in our Pain Therapy Center on 49 patients with severe oncologic pain, previously treated with opioids and other drugs associations. Our results indicated a good control of continuous nociceptive cancer pain, with a better quality of life and lesser side effects to respect the previous regime of orally opioids.
芬太尼透皮贴剂是唯一的透皮阿片类药物，是提高癌症疼痛患者生活质量的有效手段。本文简要介绍了该药物的药理特性和给药方法。当世界卫生组织镇痛阶梯第三步推荐的其他阿片类药物无效或出现难以忍受的副作用（恶心和/或呕吐、严重的黏膜损伤和吞咽困难）时，芬太尼透皮贴剂是一种有用的替代药物。我们特别指出了从口服吗啡转换为芬太尼透皮贴剂时的一些变化和调整。此外，我们报告了在我们疼痛治疗中心对49例重度肿瘤疼痛患者进行的一项研究结果，这些患者之前接受过阿片类药物和其他药物联合治疗。我们的结果表明，持续性伤害性癌症疼痛得到了良好控制，生活质量提高，且与之前的口服阿片类药物治疗方案相比，副作用更少。
