加纳药物治疗对眼压控制的影响。

The effect of medical therapy on IOP control in Ghana.

作者信息

Gyasi M E, Andrew F, Adjuik M, Kesse E, Kodjo R A, Herndon L

机构信息

Bawku Hospital - Eye Department, P.O. Box 45, Bawku, Upper East Region, Bawku, Upper East Region P.O. Box 45,Ghana And Emmanuel Eye Centre - Ophthalmology, P.O. Box Gp8769, Accra, Greater Accra Region Gp8769, Ghana.

University Of Illinois At Chicago - Ophthalmology And Visual Sciences, 1855 W Taylor St , Chicago, Illinois 60612, United States.

出版信息

Ghana Med J. 2014 Sep;48(3):148-52. doi: 10.4314/gmj.v48i3.5.

DOI:10.4314/gmj.v48i3.5

PMID:25709124

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4335445/

Abstract

BACKGROUND

To investigate IOP control following twelve months of continuous medical therapy in Ghana.

METHODS

This retrospective case series included 163 glaucoma patients diagnosed at a referral eye center between 1996 and 2006. Information collected included age, gender, IOP at presentation, six months and one year post treatment and types of anti-glaucoma medications prescribed. Optimal IOP control was defined according to results from the Advanced Glaucoma Intervention Study (AGIS), which demonstrated arrest of visual field progression in patients with IOP < 18 mmHg at all visitations: Level 1 (post-treatment IOP ≤ 21 mmHg); Level 2 (≤ 18 mmHg) and level 3 (≤ 16 mmHg). The principal outcome measure was the achievement of IOP <18 mmHg at six months and twelve month visitations.

RESULTS

One hundred sixty three patients were analyzed. These included 68 males (41.7%) and 95 females (58.3%). The mean age was 57±16 (median 59 years; range 7 - 95 years). There was no significant difference in age (p=0.35) or mean IOP (p=0.08) between genders. The mean pre-treated IOP of 31.9±8.9 mmHg significantly decreased to 21.3±6.6 mmHg at 6 months (p=0.001), with 57.4% of eyes at Level 1 IOP control, 25.3% at Level 2 and 15.4% at Level 3 and decreased further at 12 months to 20.7±6.9 mmHg (p=0.48) with 69.7% of eyes at Level 1, 34.4% at Level 2, and 12.4% at Level 3.

CONCLUSIONS

Current medical regimen is insufficient to reduce IOP to target levels as defined in the Advanced Glaucoma Intervention Study.

摘要

背景

调查加纳连续十二个月药物治疗后的眼压控制情况。

方法

该回顾性病例系列研究纳入了1996年至2006年间在一家转诊眼科中心确诊的163例青光眼患者。收集的信息包括年龄、性别、初诊时的眼压、治疗后六个月和一年的眼压以及所开抗青光眼药物的类型。最佳眼压控制是根据高级青光眼干预研究（AGIS）的结果定义的，该研究表明，在所有随访中眼压<18 mmHg的患者视野进展停止：1级（治疗后眼压≤21 mmHg）；2级（≤18 mmHg）和3级（≤16 mmHg）。主要结局指标是在六个月和十二个月随访时眼压<18 mmHg的实现情况。

结果

对163例患者进行了分析。其中包括68名男性（41.7%）和95名女性（58.3%）。平均年龄为57±16岁（中位数59岁；范围7 - 95岁）。性别之间的年龄（p = 0.35）或平均眼压（p = 0.08）无显著差异。治疗前平均眼压为31.9±8.9 mmHg，在6个月时显著降至21.3±6.6 mmHg（p = 0.001），57.4%的眼睛眼压控制在1级，25.3%在2级，15.4%在3级，在12个月时进一步降至20.7±6.9 mmHg（p = 0.48），69.7%的眼睛眼压控制在1级，34.4%在2级，12.4%在3级。