口咽癌中的人乳头瘤病毒：临床实践中需要了解的基础知识。
HPV in oropharyngeal cancer: the basics to know in clinical practice.
作者信息
Elrefaey S, Massaro M A, Chiocca S, Chiesa F, Ansarin M
机构信息
Division of Otolaryngology Head and Neck Surgery, European Institute of Oncology, Milano, Italy; ; Department of Otolaryngology, Head and Neck Surgery, Alexandria University, Alexandria, Egypt;
Division of Otolaryngology Head and Neck Surgery, European Institute of Oncology, Milano, Italy;
出版信息
Acta Otorhinolaryngol Ital. 2014 Oct;34(5):299-309.
Abstract
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising in contrast to the decreasing incidence of carcinomas in other subsites of the head and neck, in spite of the reduced prevalence of smoking. Human papilloma virus (HPV) infection, and in particular type 16 (HPV-16), is now recognized as a significant player in the onset of HPV positive OPSCC, with different epidemiological, clinical, anatomical, radiological, behavioural, biological and prognostic characteristics from HPV negative OPSCC. Indeed, the only subsite in the head and neck with a demonstrated aetiological viral link is, at present, the oropharynx. These observations lead to questions regarding management choices for patients based on tumour HPV status with important consequences on treatment, and on the role of vaccines and targeted therapy over the upcoming years.
摘要
尽管吸烟率有所下降，但与头颈部其他亚部位癌症发病率下降形成对比的是，口咽鳞状细胞癌（OPSCC）的发病率正在上升。人乳头瘤病毒（HPV）感染，尤其是16型（HPV - 16），现在被认为是HPV阳性OPSCC发病的重要因素，其具有与HPV阴性OPSCC不同的流行病学、临床、解剖学、放射学、行为学、生物学和预后特征。事实上，目前头颈部唯一已证实有病因学病毒关联的亚部位是口咽。这些观察结果引发了关于根据肿瘤HPV状态为患者选择治疗方案的问题，这对治疗以及未来几年疫苗和靶向治疗的作用都有重要影响。
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