Joseph Andrew W, D'Souza Gypsyamber
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, JHOC 6th Floor, 601 North Caroline Street, Baltimore, MD 21287, USA.
Otolaryngol Clin North Am. 2012 Aug;45(4):739-64. doi: 10.1016/j.otc.2012.04.003. Epub 2012 May 31.
Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.
人乳头瘤病毒（HPV）现已被确认为是头颈部鳞状细胞癌（HNSCC）的一个亚型的病因。尽管过度吸烟和饮酒仍是HNSCC的重要危险因素，但流行病学研究表明，现在超过25%的HNSCC是由HPV引起的。HPV相关HNSCC的发病率正在上升，这凸显了了解导致这些癌症的口腔HPV感染的必要性。本文综述了HPV与HNSCC之间因果关系的证据，研究了HNSCC不断变化的流行病学趋势，并讨论了目前关于口腔HPV感染、自然史和传播的已知情况。
