Swapnajeet Sahoo, Bn Subodh, Gourav Gupta
Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Clin Psychopharmacol Neurosci. 2016 Nov 30;14(4):402-404. doi: 10.9758/cpn.2016.14.4.402.
Apart from sleep wake disorders, nowadays, modafinil is being prescribed for several psychiatric disorders including depression. Despite being reported as to be having very low abuse potential, cases of modafinil dependence had come to the limelight. In this case report, we describe a 35 year old man with bipolar affective disorder while in remission who developed modafinil dependence and later on, had hypersexuality when he increased the dose of modafinil from 400 to 1,000 mg/day. Existing literature suggests that modafinil when taken above prescribed doses can cause many side effects ranging from nausea, vomiting to psychotic exacerbation and mania. However, hypersexuality as a side effect of modafinil overuse is not commonly seen. The exact pathophysiological mechanism of modafinil induced hypersexuality is not clear. Clinicians should be aware of possibility of modafinil leading to dependence and this rare significant side effect of modafinil.
除了睡眠-觉醒障碍外，如今，莫达非尼正被用于治疗包括抑郁症在内的多种精神疾病。尽管据报道其滥用潜力非常低，但莫达非尼依赖的案例已引起关注。在本病例报告中，我们描述了一名35岁处于缓解期的双相情感障碍男性，他出现了莫达非尼依赖，后来当他将莫达非尼剂量从每日400毫克增加到1000毫克时，出现了性欲亢进。现有文献表明，莫达非尼超过规定剂量服用会引起许多副作用，从恶心、呕吐到精神病发作和躁狂。然而，性欲亢进作为莫达非尼过度使用的副作用并不常见。莫达非尼诱发性欲亢进的确切病理生理机制尚不清楚。临床医生应意识到莫达非尼导致依赖的可能性以及这种莫达非尼罕见但严重的副作用。
