Farshchian Mahmood, Ansar Akram, Zamanian Abbas, Rahmatpour-Rokni Ghasem, Kimyai-Asadi Arash, Farshchian Mehdi
Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamedan, Iran.
Department of Dermatology, Iran University of Medical Sciences, Tehran, Iran.
Clin Cosmet Investig Dermatol. 2015 Feb 9;8:53-6. doi: 10.2147/CCID.S75849. eCollection 2015.
The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity.
The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007-2009). In 84 cases, histopathologic examination of skin biopsies were also performed.
Patients with drug reactions were found to be more commonly female (63%) than male (37%). Beta-lactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-inflammatory drugs (16.5%). Acute urticaria was the most common clinical presentation (59.2%) followed by fixed drug eruptions (18.5%), and maculopapular eruptions (14.9%).
Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fixed drug eruptions, and maculopapular rashes.
本研究旨在分析药物不良反应导致皮肤病变的患者的临床特征。
本研究纳入了308例在研究期间（2007 - 2009年）被诊断为药物不良反应的患者。其中84例还进行了皮肤活检的组织病理学检查。
发现药物反应患者中女性（63%）比男性（37%）更常见。β-内酰胺类抗生素被发现是药物不良反应最常见的原因（42.7%），其次是非甾体抗炎药（16.5%）。急性荨麻疹是最常见的临床表现（59.2%），其次是固定性药疹（18.5%）和斑丘疹（14.9%）。
我们研究人群中的药物不良反应主要由β-内酰胺类抗生素和非甾体抗炎药引起。最常见的皮肤药物不良反应形式为急性荨麻疹、固定性药疹和斑丘疹。
