Lin Xingjian, Zhang Yingdong, Liu Weiguo, Dong Jingde, Lu Jie, Di Qing, Shi Jingping
Nanjing Medical University, Affiliated Nanjing Brain Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China.
Nanjing Medical University, Affiliated Nanjing Brain Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China ; Nanjing Medical University, Affiliated Nanjing First Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China.
Neural Regen Res. 2012 Jun 5;7(16):1220-7. doi: 10.3969/j.issn.1673-5374.2012.16.003.
Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells (GM-CSF-BMSCs) into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone.
成年雄性Sprague-Dawley大鼠在大脑中动脉闭塞发作后24小时，将粒细胞-巨噬细胞集落刺激因子转染的骨髓基质细胞（GM-CSF-BMSCs）注射到缺血边界区。结果显示，与骨髓基质细胞（BMSCs）组相比，接受GM-CSF-BMSCs移植的大鼠梗死体积减小、凋亡细胞数量减少、神经功能改善、血管生成因子表达增加以及缺血边界区血管密度增加。实验结果表明，GM-CSF-BMSCs可作为缺血性中风的一种潜在治疗策略，且优于单独使用BMSCs。
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