Chen Yan, Zhao Chunling, Zhang Chunlai, Luo Lirong, Yu Guang
Department of Physiology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China.
Functional Experiment Center of Luzhou Medical College, Luzhou 646000, Sichuan Province, China.
Neural Regen Res. 2012 Jun 5;7(16):1241-6. doi: 10.3969/j.issn.1673-5374.2012.16.006.
This study aimed to explore the pathological change to hippocampal neurons and the expression of growth associated protein 43 in 21-day-old young rats following chronic intermittent hypoxia. Hematoxylin-eosin staining results showed varying degrees of degeneration and necrosis in hippocampal neurons depending on the modeling time. Immunohistochemistry revealed that growth associated protein 43 expression in young rats following chronic intermittent hypoxia decreased, but that levels were still higher than those of normal rats at each time point, especially 4 weeks after modeling. During 1-5 weeks after modeling, a slow growth in rat weight was observed. Experimental findings indicate that chronic intermittent hypoxia may induce growth dysfunction and necrosis of hippocampal neurons, as well as increase the expression of growth associated protein 43 in young rats.
本研究旨在探讨慢性间歇性低氧对21日龄幼鼠海马神经元的病理变化及生长相关蛋白43的表达情况。苏木精-伊红染色结果显示，根据建模时间不同，海马神经元出现不同程度的变性和坏死。免疫组织化学显示，慢性间歇性低氧后幼鼠生长相关蛋白43表达降低，但各时间点水平仍高于正常大鼠，尤其是建模后4周。建模后1至5周，观察到大鼠体重增长缓慢。实验结果表明，慢性间歇性低氧可能诱导幼鼠海马神经元生长功能障碍和坏死，并增加生长相关蛋白43的表达。
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