Department of Neurology and Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Center of Stroke, Beijing Institute for Brain Disorder, Capital Medical University, Beijing, China.
CNS Neurosci Ther. 2023 Feb;29(2):516-524. doi: 10.1111/cns.14064. Epub 2022 Dec 22.
Ischemic stroke is one of the major disabling health-care problem and multiple different approaches are needed to enhance rehabilitation, in which neural repair is the structural basement. Remote ischemic conditioning (RIC) is a strategy to trigger endogenous protect. RIC has been reported to play neuroprotective role in acute stage of stroke, but the effect of RIC on repair process remaining unclear. Several studies have discovered some overlapped mechanisms RIC and neural repair performs. This review provides a hypothesis that RIC is a potential therapeutic strategy on stroke rehabilitation by evaluating the existing evidence and puts forward some remaining questions to clarify and future researches to be performed in the field.
缺血性脑卒中是主要的致残性医疗保健问题之一，需要多种不同的方法来加强康复，其中神经修复是结构基础。远程缺血预处理（RIC）是一种触发内源性保护的策略。RIC 已被报道在脑卒中的急性期发挥神经保护作用，但 RIC 对修复过程的影响尚不清楚。一些研究发现了 RIC 和神经修复之间一些重叠的机制。通过评估现有证据，本文提出了一个假设，即 RIC 通过评估现有证据，提出了一些尚待澄清的问题和该领域有待进行的未来研究，是一种潜在的脑卒中康复治疗策略。
