Sarraf Payam, Azizi Sepeher, Moghaddasi Abdorreza Naser, Sahraian Mohammad Ali, Tafakhori Abbas, Ghajarzadeh Mahsa
Department of Neurology, Iranian Center of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran.
Int J Prev Med. 2014 Dec;5(12):1582-6.
Impaired quality of life (QOL) is an issue considered in patients with multiple sclerosis (MS). There are limited studies evaluated poor sleep and impaired QOL in these cases. The aim of this study was to evaluate quality of sleep and poor sleep in Iranian patients with MS and the relationship between Pittsburgh Sleep Quality Index (PSQI) score and QOL subscales.
One-hundred and fourteen cases with definite MS due to MC Donald criteria enrolled who referred to MS clinic of Sina and Imam Hospitals were enrolled. Patients asked to fill valid and reliable Persian versions of PSQI and MSQOL-54 questionnaires. Demographic data (sex, age), duration of the disease, education level and marital status were extracted from patients medical files. After neurological examination, Kurtzke Expanded Disability Status Scale (EDSS) was assessed.
Ninety-one (79.8%) patients were female and 23 (20.2%) were male. Mean age and EDSS was 34.7 ± 9.6 years and 2.3 (median: 1.5). Mean PSQI score and overall QOL score were 4.5 and 57. Sixty-seven cases were good sleepers (PSQI ≤ 5) and 47 were poor sleepers (PSQI > 5). Except five subscales, all others were significantly different between good and poor sleepers. There was significant positive correlation between PSQI score and EDSS (r = 0.24, P < 0.001) and negative correlation between EDSS and physical and mental health (r = -0.48, P < 0.001, r = -0.43, P < 0.001). EDSS and total PSQI score were independent predictors of physical and mental health composites.
Sleep quality as a factor which affecting QOL should be considered and evaluated properly in MS patients.
生活质量受损是多发性硬化症（MS）患者需考虑的一个问题。针对此类病例中睡眠不佳与生活质量受损的研究有限。本研究旨在评估伊朗MS患者的睡眠质量与睡眠不佳情况，以及匹兹堡睡眠质量指数（PSQI）得分与生活质量各子量表之间的关系。
纳入因麦当劳标准确诊为MS且转诊至新浪医院和伊玛目医院MS门诊的114例患者。患者被要求填写有效且可靠的波斯语版PSQI和MSQOL - 54问卷。从患者病历中提取人口统计学数据（性别、年龄）、病程、教育程度和婚姻状况。经神经学检查后，评估库尔特克扩展残疾状态量表（EDSS）。
91例（79.8%）患者为女性，23例（20.2%）为男性。平均年龄和EDSS分别为34.7±9.6岁和2.3（中位数：1.5）。PSQI平均得分和总体生活质量得分为4.5和57。67例为睡眠良好者（PSQI≤5），47例为睡眠不佳者（PSQI>5）。除五个子量表外，睡眠良好者与睡眠不佳者之间的所有其他方面均存在显著差异。PSQI得分与EDSS之间存在显著正相关（r = 0.24，P < 0.001），EDSS与身心健康之间存在负相关（r = -0.48，P < 0.001，r = -0.43，P < 0.001）。EDSS和PSQI总得分是身心健康综合指标的独立预测因素。
睡眠质量作为影响生活质量的一个因素，在MS患者中应得到适当考虑和评估。
