多发性硬化症中的静息-活动节律、疼痛与运动活动
Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis.
作者信息
Scherder Rogier J, van Dorp M J, Prins A J, van Klaveren C, Cornelisz I, Killestein J, Weinstein Henry C
机构信息
From the Department of Clinical Neuropsychology, Free University, Amsterdam, the Netherlands (RJS, CvK, IC).
Tante Louise, Bergen op Zoom, the Netherlands (MJvD).
出版信息
Int J MS Care. 2023 Jul-Aug;25(4):157-162. doi: 10.7224/1537-2073.2021-030. Epub 2023 Mar 8.
BACKGROUND
Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms are associated with sleep disturbances.
METHODS
Forty-six patients with MS experiencing pain participated. Sleep was indirectly measured by assessing rest-activity rhythm via actigraphy: interdaily stability, intradaily variability, and relative amplitude. Pain was assessed using visual and verbal analog scales, mood by the Beck Depression Inventory and Symptom Checklist-90, and physical disability by the Expanded Disability Status Scale.
RESULTS
Incorporating mood, pain, and physical disability into 1 regression model resulted in a significant association with interdaily stability.
CONCLUSIONS
Compared with intradaily variability and relative amplitude, interdaily stability seems to be the most vulnerable actigraphy variable for mood disturbances, pain, and physical disabilities.
背景
尽管在多发性硬化症（MS）中，身体残疾、情绪障碍和疼痛之间的关系已有详尽描述，但对于这些症状是否与睡眠障碍相关却知之甚少。
方法
46名患有疼痛的MS患者参与研究。通过活动记录仪评估休息 - 活动节律来间接测量睡眠：日间稳定性、日内变异性和相对振幅。使用视觉和言语模拟量表评估疼痛，通过贝克抑郁量表和症状自评量表90评估情绪，采用扩展残疾状态量表评估身体残疾。
结果
将情绪、疼痛和身体残疾纳入一个回归模型，结果显示与日间稳定性存在显著关联。
结论
与日内变异性和相对振幅相比，日间稳定性似乎是活动记录仪测量中最易受情绪障碍、疼痛和身体残疾影响的变量。
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