石榴花提取物不能预防顺铂诱导的雌性大鼠肾毒性。
Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats.
作者信息
Jilanchi Sima, Nematbakhsh Mehdi, Mazaheri Safoora, Talebi Ardeshir, Zolfaghari Behzad, Pezeshki Zahra, Eshraghi-Jazi Fatemeh, Moeini Maryam
机构信息
Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Physiology, Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran ; Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran.
出版信息
Int J Prev Med. 2014 Dec;5(12):1621-5.
BACKGROUND
Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats.
METHODS
Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for 9 days, and from day 3 on, they also received cisplatin (CDDP) (2.5 mg/kg) daily. Group 3 was treated as group 1 expects saline instead of PFE, and group 4 received PFE (25 mg/kg/day) alone.
RESULTS
Cisplatin alone increased the serum levels of blood urea nitrogen, creatinine, and nitrite; and kidney tissue damage score and kidney weight. However, PFE not only did not ameliorate the induced nephrotoxicity, but also aggravated renal tissue damage.
CONCLUSIONS
Pomegranate extract as an antioxidant did not ameliorate CDDP-induced nephrotoxicity in female rats.
背景
肾毒性是顺铂（CDDP）的主要副作用，且据报道存在性别相关性。我们评估了石榴花提取物（PFE）作为抗氧化剂对顺铂诱导的雌性大鼠肾毒性的影响。
方法
23只成年雌性大鼠分为四组，分组如下。第1组和第2组分别以25和50（毫克/千克/天）的剂量接受PFE，持续9天，从第3天起，它们还每天接受顺铂（CDDP）（2.5毫克/千克）。第3组的处理方式与第1组相同，但用生理盐水代替PFE，第4组单独接受PFE（25毫克/千克/天）。
结果
单独使用顺铂会增加血清中血尿素氮、肌酐和亚硝酸盐的水平；以及肾组织损伤评分和肾脏重量。然而，PFE不仅没有改善诱导的肾毒性，反而加重了肾组织损伤。
结论
作为抗氧化剂的石榴提取物并不能改善顺铂诱导的雌性大鼠肾毒性。
Zotero 插件