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The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity.生物标志物肾损伤分子-1（KIM-1）在顺铂诱导的肾毒性急性肾损伤（AKI）中的预测作用。
Int J Mol Sci. 2019 Oct 22;20(20):5238. doi: 10.3390/ijms20205238.
2
Recent Advances in Models, Mechanisms, Biomarkers, and Interventions in Cisplatin-Induced Acute Kidney Injury.顺铂诱导急性肾损伤的模型、机制、生物标志物及干预措施的最新进展。
Int J Mol Sci. 2019 Jun 20;20(12):3011. doi: 10.3390/ijms20123011.
3
A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.谷胱甘肽转移酶 P1-1 介导的顺铂耐药的基于结构的机制。
Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13943-13951. doi: 10.1073/pnas.1903297116. Epub 2019 Jun 20.
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Has vitamin E any shreds of evidence in cisplatin-induced toxicity.维生素 E 对顺铂诱导的毒性有何影响。
J Biochem Mol Toxicol. 2019 Aug;33(8):e22349. doi: 10.1002/jbt.22349. Epub 2019 May 21.
5
Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity.天然产物在顺铂诱导的肾毒性中的保护作用。
Mini Rev Med Chem. 2019;19(14):1134-1143. doi: 10.2174/1389557519666190320124438.
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Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity.顺铂诱导肾毒性的分子机制：在保护肾脏和肿瘤毒性之间的平衡。
J Biomed Sci. 2019 Mar 13;26(1):25. doi: 10.1186/s12929-019-0518-9.
7
Role of food-derived antioxidants against cisplatin induced-nephrotoxicity.食物来源的抗氧化剂对抗顺铂诱导的肾毒性的作用。
Food Chem Toxicol. 2018 Oct;120:230-242. doi: 10.1016/j.fct.2018.07.018. Epub 2018 Jul 7.
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An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation.氧化还原调控途径中 S-谷胱甘肽化循环的不断发展。
Free Radic Biol Med. 2018 May 20;120:204-216. doi: 10.1016/j.freeradbiomed.2018.03.038. Epub 2018 Mar 23.
9
Estrogen-related receptor α is essential for maintaining mitochondrial integrity in cisplatin-induced acute kidney injury.雌激素相关受体α对于维持顺铂诱导的急性肾损伤中的线粒体完整性至关重要。
Biochem Biophys Res Commun. 2018 Apr 15;498(4):918-924. doi: 10.1016/j.bbrc.2018.03.080. Epub 2018 Mar 16.
10
NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation.NADPH 氧化酶 4 通过 ROS 介导的程序性细胞死亡和炎症促进顺铂诱导的急性肾损伤。
Lab Invest. 2018 Jan;98(1):63-78. doi: 10.1038/labinvest.2017.120. Epub 2017 Nov 6.

顺铂化疗与肾功能。

Cisplatin chemotherapy and renal function.

机构信息

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.

出版信息

Adv Cancer Res. 2021;152:305-327. doi: 10.1016/bs.acr.2021.03.008. Epub 2021 Apr 28.

DOI:10.1016/bs.acr.2021.03.008
PMID:34353441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8963537/
Abstract

Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. This review details those biochemical pathways and metabolic conversions that underlie the kidney toxicities. A wide range of redox events contribute to the eventual physiological consequences of drug activities.

摘要

顺铂自 20 世纪 70 年代以来一直是癌症化疗的主要药物。尽管其具有广泛的抗癌潜力，但由于肾毒性，其临床应用经常受到限制。本综述详细介绍了那些构成肾毒性基础的生化途径和代谢转化。广泛的氧化还原事件导致了药物活性的最终生理后果。