顺铂化疗与肾功能。
Cisplatin chemotherapy and renal function.
机构信息
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.
出版信息
Adv Cancer Res. 2021;152:305-327. doi: 10.1016/bs.acr.2021.03.008. Epub 2021 Apr 28.
Abstract
Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. This review details those biochemical pathways and metabolic conversions that underlie the kidney toxicities. A wide range of redox events contribute to the eventual physiological consequences of drug activities.
摘要
顺铂自 20 世纪 70 年代以来一直是癌症化疗的主要药物。尽管其具有广泛的抗癌潜力，但由于肾毒性，其临床应用经常受到限制。本综述详细介绍了那些构成肾毒性基础的生化途径和代谢转化。广泛的氧化还原事件导致了药物活性的最终生理后果。
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2
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