川崎病后无冠状动脉并发症患者内皮细胞损伤的晚期持续性
Persistence of endothelial cell damage late after Kawasaki disease in patients without coronary artery complications.
作者信息
Mostafavi Nasser, Haghjooy-Javanmard Shaghayegh, Presidend Nahid, Manssori Nayereh Siyah, Kelishadi Roya
机构信息
Department of Pediatrics, Infectious Diseases and Tropical Medicine Research Center, Isfahan, Iran ; Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Adv Biomed Res. 2015 Jan 30;4:25. doi: 10.4103/2277-9175.150393. eCollection 2015.
BACKGROUND
Recent studies proposed an increased risk of atherosclerosis in patients with a history of Kawasaki disease. This study aimed to investigate the persistence of vascular injury after an acute phase of the Kawasaki disease.
MATERIALS AND METHODS
We determined the number of circulating endothelial cells (CEC) in the peripheral blood of 13 patients with a history of Kawasaki disease within four to ten years, in comparison with 13 healthy relative controls. The CECs were counted as CD146+/CD34 + cells by the standard flow cytometry technique, and the independent t-test was employed to compare the mean number of CECs in the two groups.
RESULTS
The mean number of CECs was significantly higher in patients than in controls (12 ± 3.03 vs. 2.38 ± 0.87, respectively, P < 0.001).
CONCLUSION
This study elucidates the persistence of vascular injury late after Kawasaki disease. This finding suggests that prolonged administration of vascular anti-inflammatory agents might be beneficial for preventing atherosclerosis in the subsequent years, in these patients.
背景
近期研究表明，有川崎病病史的患者患动脉粥样硬化的风险增加。本研究旨在调查川崎病急性期后血管损伤的持续性。
材料与方法
我们测定了13例有川崎病病史4至10年患者外周血中循环内皮细胞（CEC）的数量，并与13名健康亲属对照进行比较。通过标准流式细胞术将CEC计为CD146+/CD34 +细胞，并采用独立t检验比较两组CEC的平均数量。
结果
患者的CEC平均数量显著高于对照组（分别为12±3.03和2.38±0.87，P<0.001）。
结论
本研究阐明了川崎病后期血管损伤的持续性。这一发现表明，长期给予血管抗炎药物可能有助于预防这些患者在随后几年发生动脉粥样硬化。
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