Mostafavi Seyyed-Naserredin, Barzegar Elham, Manssori Nayereh Siyah, Kelishadi Roya
Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Pediatrics, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pediatric Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2014 Jul;5(7):820-4.
Concerns have been raised about the possibility of a predisposition of Kawasaki disease (KD) to abnormal lipid profile after an acute phase of disease, which can predispose them to premature atherosclerosis later in life. We determined the lipid profile of children late after KD, and compared it with controls.
This historical cohort was conducted on 32 subjects: 16 children with history of uncomplicated KD (age 11.8 ± 3.3 years, interval from the initial episode 7.1 years), and 16 healthy age-matched of their sibling or cousins. Fasting serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) levels were compared between groups. In addition, blood pressure and body mass index (BMI) were measured and compared.
Six out of 16 KD patients and 7 out of 16 controls had abnormal lipid values. No significant difference was found in mean values of systolic blood pressures, diastolic blood pressures, BMI, TG, TC, HDL-C, and LDL-C between cases and controls.
We conclude that although Iranian KD children probably had no different lipid profile compared with controls, but due to finding dyslipidemia in more than one-third of KD subjects, we suggest that periodic control of lipid values in these patients is of crucial importance.
有人担心川崎病（KD）患者在急性期后可能易出现血脂异常，这可能使他们在晚年易患早发性动脉粥样硬化。我们测定了KD患儿后期的血脂情况，并与对照组进行比较。
对32名受试者进行了这项历史性队列研究：16名有单纯KD病史的儿童（年龄11.8±3.3岁，距初次发病间隔7.1年），以及16名与其年龄匹配的健康同胞或表亲。比较两组间空腹血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）水平。此外，测量并比较血压和体重指数（BMI）。
16名KD患者中有6名和16名对照组中有7名血脂值异常。病例组和对照组的收缩压、舒张压、BMI、TG、TC、HDL-C和LDL-C平均值之间未发现显著差异。
我们得出结论，虽然伊朗KD患儿的血脂情况可能与对照组无差异，但由于超过三分之一的KD患者存在血脂异常，我们建议对这些患者定期进行血脂值监测至关重要。
