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2
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对受艾滋病毒感染、社会边缘化成年人的最低点CD4细胞计数和最近艾滋病毒载量的回顾

Recall of Nadir CD4 Cell Count and Most Recent HIV Viral Load Among HIV-Infected, Socially Marginalized Adults.

作者信息

Buisker Timothy R, Dufour Mi-Suk Kang, Myers Janet J

机构信息

Department of Medicine, Center for AIDS Prevention Studies, University of California - San Francisco, 550 16th St., 3rd Floor, UCSF Mailcode 0886, San Francisco, CA, 94158, USA.

Division of Epidemiology, School of Public Health, University of California - Berkeley, Berkeley, CA, USA.

出版信息

AIDS Behav. 2015 Nov;19(11):2108-16. doi: 10.1007/s10461-015-1018-x.

DOI:10.1007/s10461-015-1018-x
PMID:25711297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4579050/
Abstract

Lower nadir CD4 cell counts and higher HIV viral loads are associated with increased risks of adverse events in the progression of HIV disease. In cases where medical records are inaccessible or incomplete, little evidence is available regarding whether nadir CDR cell count or HIV viral load is reliably reported in any patient population. We compare survey data collected from 207 HIV-infected individuals detained in San Francisco jails to data collected from electronic medical records (EMR) kept by the jails and community health providers. The sensitivity of self-reported nadir CD4 cell count less than 200 was 82 % [95 % confidence interval (CI) 68, 88], and the sensitivity of reporting an undetectable most recent HIV viral load was 93 % (95 % CI 84, 97). This suggests that in a highly socially marginalized population, nadir CD4 cell count and most recent HIV viral load are recalled accurately when compared to EMR.

摘要

更低的最低点CD4细胞计数和更高的HIV病毒载量与HIV疾病进展中不良事件风险增加相关。在无法获取或不完整病历的情况下,几乎没有证据表明在任何患者群体中最低点CD4细胞计数或HIV病毒载量是否得到可靠报告。我们将从旧金山监狱中被拘留的207名HIV感染者收集的调查数据与监狱和社区卫生服务提供者保存的电子病历(EMR)数据进行比较。自我报告的最低点CD4细胞计数低于200的敏感度为82%[95%置信区间(CI)68,88],报告最近HIV病毒载量检测不到的敏感度为93%(95%CI 84,97)。这表明在一个高度社会边缘化的人群中,与电子病历相比,最低点CD4细胞计数和最近的HIV病毒载量能被准确回忆。