高山岩黄芪种子中L-刀豆氨酸的存在及其在克里斯·麦克坎德莱斯死亡中可能扮演的角色。
Presence of L-canavanine in Hedysarum alpinum seeds and its potential role in the death of Chris McCandless.
作者信息
Krakauer Jon, Long Ying, Kolbert Andrew, Thanedar Shri, Southard Jonathan
机构信息
Knopf Doubleday Publishing Group, New York, NY (Mr Krakauer).
Avomeen Analytical Services, Ann Arbor, MI (Drs Long, Kolbert, and Thanedar).
出版信息
Wilderness Environ Med. 2015 Mar;26(1):36-42. doi: 10.1016/j.wem.2014.08.014.
OBJECTIVE
For the past 2 decades there has been vigorous disagreement over the purported toxicity of Hedysarum alpinum seeds, and whether the consumption of such seeds was a factor in the 1992 death of Chris McCandless, the subject of the book Into the Wild. Our objective was to confirm or disprove the presence of L-canavanine (a nonprotein amino acid known to induce systemic lupuslike symptoms in humans) in H alpinum seeds.
METHODS
Liquid chromatography-tandem mass spectrometry analysis of H alpinum seeds was performed.
RESULTS
Our analysis confirmed the presence of L-canavanine in H alpinum seeds and demonstrated that it is a significant component of the seeds, with a concentration of 1.2% (weight/weight), roughly half of that found in Canavalia ensiformis.
CONCLUSIONS
The data led us to conclude it is highly likely that the consumption of H alpinum seeds contributed to the death of Chris McCandless.
目的
在过去20年里，对于高山岩黄芪种子所谓的毒性，以及食用此类种子是否是《荒野生存》一书中所讲述的克里斯·麦坎德利斯在1992年死亡的一个因素，一直存在激烈的争论。我们的目的是证实或证伪高山岩黄芪种子中是否存在L-刀豆氨酸（一种已知会在人类身上诱发系统性红斑狼疮样症状的非蛋白质氨基酸）。
方法
对高山岩黄芪种子进行液相色谱-串联质谱分析。
结果
我们的分析证实了高山岩黄芪种子中存在L-刀豆氨酸，并表明它是种子的一种重要成分，浓度为1.2%（重量/重量），大约是在白刀豆中发现浓度的一半。
结论
这些数据使我们得出结论，食用高山岩黄芪种子极有可能是克里斯·麦坎德利斯死亡的原因。
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