Li Xijing, Zou Gang
Department of Fine Chemicals, East China University of Science & Technology, 130 Meilong Road, Shanghai, P. R. China.
Chem Commun (Camb). 2015 Mar 25;51(24):5089-92. doi: 10.1039/c5cc00430f.
A highly efficient palladium-catalyzed acylative cross-coupling of carboxylic amides with arylboronic acids has been achieved via synergistic activation of the C(acyl)-N bond by independently modifiable activating groups. Coupling of amides features not only good functional group tolerance but also modifiable reactivities to overcome steric hindrance.
通过可独立修饰的活化基团对C（酰基）-N键的协同活化，实现了钯催化的羧酰胺与芳基硼酸的高效酰基化交叉偶联反应。酰胺的偶联不仅具有良好的官能团耐受性，而且具有可修饰的反应活性以克服空间位阻。
