Akinci Gulcin, Oztura Ibrahim, Hiz Semra, Akdogan Ozlem, Karaarslan Dilay, Ozek Handan, Akay Aynur
Department of Pediatric Neurology, Dr Behcet Uz Children's Hospital, Izmir, Turkey
Sleep Disease Center, Department of Neurology, Dokuz Eylul University, Izmir, Turkey.
J Child Neurol. 2015 Oct;30(11):1520-5. doi: 10.1177/0883073815573318. Epub 2015 Feb 23.
The authors evaluated basic sleep architecture and non-rapid eye movement (NREM) sleep alterations in drug-naïve attention-deficit/hyperactivity disorder (ADHD) children without psychiatric or other comorbidities. This cross-sectional case-control study included 28 drug-naïve children with ADHD and 15 healthy controls. This subjective studies revealed that children with ADHD had a worse sleep quality and increased daytime sleepiness. Polysomnography data showed that the sleep macrostructure was not significantly different in children with ADHD. Sleep microstructure was altered in ADHD children by means of reduced total cyclic alternating pattern rate and duration of cyclic alternating pattern sequences. This reduction was associated with a selective decrease of A1 index during stage 2 NREM. SpO2 in total sleep was slightly decreased; however, the incidence of sleep disordered breathing showed no significant difference. The authors suggest that cyclic alternating pattern scoring would provide a further insight to obtain a better understanding of the sleep structure in children with ADHD.
作者评估了未服用过药物、无精神疾病或其他合并症的注意缺陷多动障碍（ADHD）儿童的基本睡眠结构和非快速眼动（NREM）睡眠改变情况。这项横断面病例对照研究纳入了28名未服用过药物的ADHD儿童和15名健康对照者。这项主观研究表明，ADHD儿童的睡眠质量较差，白天嗜睡增加。多导睡眠图数据显示，ADHD儿童的睡眠宏观结构无显著差异。ADHD儿童的睡眠微观结构发生改变，表现为总周期性交替模式率降低和周期性交替模式序列持续时间缩短。这种降低与NREM 2期期间A1指数的选择性降低有关。总睡眠期间的血氧饱和度（SpO2）略有下降；然而，睡眠呼吸障碍的发生率无显著差异。作者建议，周期性交替模式评分将有助于进一步深入了解ADHD儿童的睡眠结构。
