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Solving the riddle of the sphinx may provide new insights into diabetes and polyneuropathy.

作者信息

Klein Christopher J

机构信息

Department of Neurology, Department of Laboratory Medicine and Pathology, and Department of Medical Genetics, Mayo Clinic, Rochester, MN

出版信息

Diabetes. 2015 Mar;64(3):706-8. doi: 10.2337/db14-1632.

DOI:10.2337/db14-1632
PMID:25713196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4876741/
Abstract
摘要

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Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats.降低血浆 1-脱氧神经酰胺可改善糖尿病大鼠的神经病变。
Diabetes. 2015 Mar;64(3):1035-45. doi: 10.2337/db14-1325. Epub 2014 Oct 2.
2
Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells.脱氧鞘氨醇脂质,2 型糖尿病的新型生物标志物,对胰岛素分泌细胞具有细胞毒性。
Diabetes. 2014 Apr;63(4):1326-39. doi: 10.2337/db13-1042. Epub 2013 Dec 30.
3
Sphingolipids and atherosclerosis.鞘脂类与动脉粥样硬化。
Atherosclerosis. 2013 Jan;226(1):16-28. doi: 10.1016/j.atherosclerosis.2012.08.041. Epub 2012 Sep 29.
4
Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?血浆神经酰胺:代谢综合征的新型生物标志物?
Diabetologia. 2012 Feb;55(2):421-31. doi: 10.1007/s00125-011-2384-1. Epub 2011 Nov 29.
5
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.口服 L-丝氨酸补充可减少遗传性感觉自主神经病 1 型小鼠和人类中神经毒性去氧神经鞘脂的产生。
J Clin Invest. 2011 Dec;121(12):4735-45. doi: 10.1172/JCI57549.
6
The debut of a rational treatment for an inherited neuropathy?遗传性神经病的合理治疗方法问世?
J Clin Invest. 2011 Dec;121(12):4624-7. doi: 10.1172/JCI60511.
7
Diabetic neuropathy: cellular mechanisms as therapeutic targets.糖尿病神经病变:细胞机制作为治疗靶点。
Nat Rev Neurol. 2011 Sep 13;7(10):573-83. doi: 10.1038/nrneurol.2011.137.
8
Deoxysphingoid bases as plasma markers in diabetes mellitus.脱氧鞘氨醇碱基作为糖尿病的血浆标志物。
Lipids Health Dis. 2010 Aug 16;9:84. doi: 10.1186/1476-511X-9-84.
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Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids.遗传性感觉神经病 1 型是由两种神经毒性鞘脂的积累引起的。
J Biol Chem. 2010 Apr 9;285(15):11178-87. doi: 10.1074/jbc.M109.092973. Epub 2010 Jan 22.
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Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction.神经系统中的鞘脂类和神经节苷脂在膜功能和功能障碍中的作用。
FEBS Lett. 2010 May 3;584(9):1748-59. doi: 10.1016/j.febslet.2009.12.010. Epub 2009 Dec 17.