神经系统中的鞘脂类和神经节苷脂在膜功能和功能障碍中的作用。

Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction.

机构信息

Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.

出版信息

FEBS Lett. 2010 May 3;584(9):1748-59. doi: 10.1016/j.febslet.2009.12.010. Epub 2009 Dec 17.

DOI:10.1016/j.febslet.2009.12.010

PMID:20006608

Abstract

Simple sphingolipids such as ceramide and sphingomyelin (SM) as well as more complex glycosphingolipids play very important roles in cell function under physiological conditions and during disease development and progression. Sphingolipids are particularly abundant in the nervous system. Due to their amphiphilic nature they localize to cellular membranes and many of their roles in health and disease result from membrane reorganization and from lipid interaction with proteins within cellular membranes. In this review we discuss some of the functions of sphingolipids in processes that entail cellular membranes and their role in neurodegenerative diseases, with an emphasis on SM, ceramide and gangliosides.

摘要

简单的鞘脂类物质，如神经酰胺和鞘磷脂（SM），以及更复杂的糖鞘脂，在生理条件下以及在疾病发生和发展过程中，对细胞功能起着非常重要的作用。鞘脂类物质在神经系统中特别丰富。由于其两亲性，它们定位于细胞膜中，它们在健康和疾病中的许多作用源于膜重组以及脂质与细胞膜内蛋白质的相互作用。在这篇综述中，我们讨论了鞘脂类物质在涉及细胞膜的过程中的一些功能，以及它们在神经退行性疾病中的作用，重点是 SM、神经酰胺和神经节苷脂。