国际基础与临床药理学联合会。XCIV. 黏附G蛋白偶联受体。
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
作者信息
Hamann Jörg, Aust Gabriela, Araç Demet, Engel Felix B, Formstone Caroline, Fredriksson Robert, Hall Randy A, Harty Breanne L, Kirchhoff Christiane, Knapp Barbara, Krishnan Arunkumar, Liebscher Ines, Lin Hsi-Hsien, Martinelli David C, Monk Kelly R, Peeters Miriam C, Piao Xianhua, Prömel Simone, Schöneberg Torsten, Schwartz Thue W, Singer Kathleen, Stacey Martin, Ushkaryov Yuri A, Vallon Mario, Wolfrum Uwe, Wright Mathew W, Xu Lei, Langenhan Tobias, Schiöth Helgi B
机构信息
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (J.H.); Department of Surgery, Research Laboratories (G.A), and Institute of Biochemistry (I.L., S.P., T.S.), Medical Faculty, University of Leipzig, Leipzig, Germany; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois (D.A.); Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.B.E.); MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom (C.F.); Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden (R.F., A.K., H.B.S.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.A.H.); Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri (B.L.H., K.R.M.); Department for Andrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (C.K.); Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Germany (B.K., U.W.); Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan (H.-H.L.); Department of Molecular and Cellular Physiology (D.C.M.) and Division of Hematology (M.V.), Stanford University School of Medicine, Stanford, California; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (M.C.P.); Department of Neuroscience and Pharmacology and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark (M.C.P., T.W.S.); Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (X.P., K.S.); Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom (M.S.); Medway School of Pharmacy, University of Kent, Chatham, United Kingdom (Y.A.U.); HUGO Gene Nomen
出版信息
Pharmacol Rev. 2015;67(2):338-67. doi: 10.1124/pr.114.009647.
The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.
粘附家族构成了药理学上重要的G蛋白偶联受体（GPCRs）超家族的一个大分支。随着粘附GPCRs越来越受到广泛生物医学领域的关注，粘附GPCRs联盟与国际基础与临床药理学联合会受体命名和药物分类委员会一起，提出了粘附GPCRs的统一命名法。新名称以ADGR作为共同标识符，后面跟着一个字母和一个数字，分别表示每个亚家族和亚型。新名称（括号内为旧名称和替代名称）如下：ADGRA1（GPR123）、ADGRA2（GPR124）、ADGRA3（GPR125）、ADGRB1（BAI1）、ADGRB2（BAI2）、ADGRB3（BAI3）、ADGRC1（CELSR1）、ADGRC2（CELSR2）、ADGRC3（CELSR3）、ADGRD1（GPR133）、ADGRD2（GPR144）、ADGRE1（EMR1，F4/80）、ADGRE2（EMR2）、ADGRE3（EMR3）、ADGRE4（EMR4）、ADGRE5（CD97）、ADGRF1（GPR110）、ADGRF2（GPR111）、ADGRF3（GPR113）、ADGRF4（GPR115）、ADGRF5（GPR116，Ig-Hepta）、ADGRG1（GPR56）、ADGRG2（GPR64，HE6）、ADGRG3（GPR97）、ADGRG4（GPR112）、ADGRG5（GPR114）、ADGRG6（GPR126）、ADGRG7（GPR128）、ADGRL1（亲嗜素-1，CIRL-1，CL1）、ADGRL2（亲嗜素-2，CIRL-2，CL2）、ADGRL3（亲嗜素-3，CIRL-3，CL3）、ADGRL4（ELTD1，ETL）和ADGRV1（VLGR1，GPR98）。本综述涵盖了粘附GPCRs的所有主要生物学方面，包括进化起源、相互作用伙伴、信号传导、表达、生理功能和治疗潜力。
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