Afarideh Mohsen, Behdadnia Aram, Noshad Sina, Mirmiranpour Hossein, Mousavizadeh Mostafa, Khajeh Elias, Rad Mona Vahidi, Mazaheri Tina, Nakhjavani Manouchehr, Esteghamati Alireza
Endocr Pract. 2015 Jul;21(7):711-8. doi: 10.4158/EP14442.OR. Epub 2015 Feb 25.
The constellation of metabolic abnormalities seen in metabolic syndrome (MetS) has been linked to atherosclerosis and adverse cardiovascular outcomes due to heightened inflammation. Accumulating evidence suggests that peripheral 5-hydroxyindole-3-acetic acid (5-HIAA), the derivative end-product of serotonin (5-HT), might be involved in the pathogenesis of obesity, and abnormal lipid and glucose metabolism. We examined the association between serum 5-HIAA concentrations and MetS and also highly sensitive C-reactive protein (hsCRP).
We assessed 180 healthy adults (110 males and 70 females) in a cross-sectional setting. Anthropometric indices and blood pressure were measured, as were laboratory parameters including fasting 5-HIAA concentrations. The associations between 5-HIAA and individual components of MetS, as well as MetS as a single entity, were investigated with bivariate correlation and logistic regression analyses.
Eighty-nine individuals (49.4%) were diagnosed with MetS. Significant correlations were found between 5-HIAA concentrations and age (r = 0.184), waist circumference (r = 0.415), high-density lipoprotein (HDL) cholesterol (r = -0.148), systolic blood pressure (r = 0.374), diastolic blood pressure (r = 0.355), homeostasis model assessment of insulin resistance (r = 0.201), and hsCRP (r = 0.453) were found (P<.05 in all tests). In logistic regression, 5-HIAA was significantly associated with 4 MetS components including central obesity, raised triglycerides, raised blood pressure, and raised fasting plasma glucose (FPG) (P<.05). Moreover, 5-HIAA was a predictor of MetS as a single entity, and the relationship persisted after adjusting for hsCRP (odds ratio [OR] = 4.41, 95% confidence interval [CI]: 2.58-7.67, P<.001).
Elevated concentrations of 5-HIAA are seen in individuals with MetS. Increased 5-HIAA is also associated with hsCRP, a marker of chronic low-grade inflammation underlying MetS.
代谢综合征（MetS）中出现的一系列代谢异常与动脉粥样硬化及不良心血管结局有关，这是由于炎症加剧所致。越来越多的证据表明，外周5-羟色胺（5-HT）的衍生物终产物5-羟吲哚-3-乙酸（5-HIAA）可能参与肥胖、脂质和葡萄糖代谢异常的发病机制。我们研究了血清5-HIAA浓度与MetS以及高敏C反应蛋白（hsCRP）之间的关联。
我们对180名健康成年人（110名男性和70名女性）进行了横断面研究。测量了人体测量指标和血压，以及包括空腹5-HIAA浓度在内的实验室参数。通过双变量相关性分析和逻辑回归分析，研究了5-HIAA与MetS各组成成分以及作为一个整体的MetS之间的关联。
89人（49.4%）被诊断为MetS。发现5-HIAA浓度与年龄（r = 0.184）、腰围（r = 0.415）、高密度脂蛋白（HDL）胆固醇（r = -0.148）、收缩压（r = 0.374）、舒张压（r = 0.355）、胰岛素抵抗的稳态模型评估（r = 0.201）和hsCRP（r = 0.453）之间存在显著相关性（所有检验P<0.05）。在逻辑回归中，5-HIAA与包括中心性肥胖、甘油三酯升高、血压升高和空腹血糖（FPG）升高在内的4个MetS组成成分显著相关（P<0.05）。此外，5-HIAA是作为一个整体的MetS的预测指标，在调整hsCRP后这种关系仍然存在（比值比[OR] = 4.41，95%置信区间[CI]：2.58 - 7.67，P<0.001）。
MetS患者的5-HIAA浓度升高。5-HIAA升高还与hsCRP相关，hsCRP是MetS潜在慢性低度炎症的标志物。
