Suda Tatsuo
Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.
Clin Calcium. 2015 Mar;25(3):349-58.
Vitamin D3 is already found in the early evolution of life, but essentially as inactive products of the photochemical reaction of 7-dehydrocholesterol. The full vitamin D endocrine system characterized by the specific vitamin D transport protein (DBP) , specific vitamin D-metabolizing CYP P450 enzymes, active vitamin D metabolites, 1α,25 (OH) 2D3, specific vitamin D nuclear receptor (VDR), and fibroblast growth factor 23 (FGF23) became essential for maintaining calcium and bone homeostasis in terrestrial animals cope with the challenging of higher gravity and calcium-poor environment. The present review describes the story about the evolution of animals and vitamin D.
维生素D3在生命的早期进化中就已存在，但基本上是7-脱氢胆固醇光化学反应的无活性产物。以特定的维生素D转运蛋白（DBP）、特定的维生素D代谢CYP P450酶、活性维生素D代谢产物1α,25（OH）2D3、特定的维生素D核受体（VDR）和成纤维细胞生长因子23（FGF23）为特征的完整维生素D内分泌系统，对于陆地动物应对更高重力和缺钙环境的挑战、维持钙和骨骼稳态至关重要。本综述描述了动物与维生素D的进化历程。
