van Driel Marjolein, van Leeuwen Johannes P T M
Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
Department of Research and Education, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
Mol Cell Endocrinol. 2017 Sep 15;453:46-51. doi: 10.1016/j.mce.2017.06.008. Epub 2017 Jun 9.
Bone is a dynamic tissue that is strongly influenced by endocrine factors to restore the balance between bone resorption and bone formation. Bone formation involves the mineralization of the extracellular matrix formed by osteoblasts. In this process the role of vitamin D (1α,25(OH)D) is both direct and indirect. The direct effects are enabled via the Vitamin D Receptor (VDR); the outcome is dependent on the presence of other factors as well as origin of the osteoblasts, treatment procedures and species differences. Vitamin D stimulates mineralization of human osteoblasts but is often found inhibitory for mineralization of murine osteoblasts. In this review we will overview the current knowledge of the role of the vitamin D endocrine system in controlling the mineralization process in bone.
骨骼是一种动态组织，受内分泌因素的强烈影响，以恢复骨吸收与骨形成之间的平衡。骨形成涉及成骨细胞形成的细胞外基质的矿化。在这个过程中，维生素D（1α,25(OH)D）的作用既有直接的也有间接的。直接作用是通过维生素D受体（VDR）实现的；其结果取决于其他因素的存在以及成骨细胞的来源、处理程序和物种差异。维生素D刺激人类成骨细胞的矿化，但通常发现对小鼠成骨细胞的矿化有抑制作用。在这篇综述中，我们将概述维生素D内分泌系统在控制骨矿化过程中作用的当前知识。
