Gilbert D B, Cooper S J
School of Psychology, University of Birmingham, U.K.
Pharmacol Biochem Behav. 1989 Apr;32(4):945-8. doi: 10.1016/0091-3057(89)90063-4.
Male rats were adapted to a 22-hr water-deprivation schedule, and to a 15-min choice test, in which water was available in one drinking tube, and water, 0.064%, 0.16%, 0.4%, 1.0%, or 2.5% NaCl solution, respectively, was available in a second. A typical saline preference-aversion function was obtained. The selective dopamine D-1 agonist, SK&F 38393 (3.0 mg/kg, IP), significantly depressed choice of hypertonic saline solutions (1.0% and 2.5% NaCl solutions), without affecting preference for hypotonic saline solutions. In contrast, the selective dopamine D-1 antagonist, SCH 23390 (0.1 mg/kg, SC), significantly increased the preference measure in the case of hypertonic solutions. These data indicate a role for D-1 receptors in dopaminergic mediation of the descending limb of the saline preference-aversion function.
雄性大鼠先适应22小时禁水方案，再适应15分钟选择测试，测试中一根饮水管提供水，另一根饮水管分别提供水、0.064%、0.16%、0.4%、1.0%或2.5%的氯化钠溶液。获得了典型的盐偏好-厌恶函数。选择性多巴胺D-1激动剂SK&F 38393（3.0毫克/千克，腹腔注射）显著降低了对高渗盐溶液（1.0%和2.5%氯化钠溶液）的选择，而不影响对低渗盐溶液的偏好。相反，选择性多巴胺D-1拮抗剂SCH 23390（0.1毫克/千克，皮下注射）在高渗溶液的情况下显著增加了偏好指标。这些数据表明D-1受体在多巴胺能介导盐偏好-厌恶函数下降支中发挥作用。
