Van Wimersma Greidanus T B, Maigret C, Torn M, Ronner E, Van der Kracht S, Van der Wee N J, Versteeg D H
Rudolf Magnus Institute, Utrecht, The Netherlands.
Eur J Pharmacol. 1989 Dec 7;173(2-3):227-31. doi: 10.1016/0014-2999(89)90527-x.
The administration of the dopamine D-1 receptor antagonist, SCH 23390, but not of the dopamine D-2 receptor antagonist, sulpiride, suppressed the excessive grooming induced by a new environment or by various neuropeptides. In addition, administration of the dopamine D-1 agonist, SK & F 38393, induced excessive grooming but that of the dopamine D-2 agonist, quinpirole, did not. It is suggested that dopamine D-1 rather than D-2 receptor stimulation is an important mechanism underlying novelty-induced as well as neuropeptide-induced excessive grooming.
给予多巴胺D-1受体拮抗剂SCH 23390可抑制由新环境或各种神经肽诱导的过度梳理行为，但给予多巴胺D-2受体拮抗剂舒必利则无此作用。此外，给予多巴胺D-1激动剂SK&F 38393可诱导过度梳理行为，而给予多巴胺D-2激动剂喹吡罗则不会。这表明多巴胺D-1受体而非D-2受体的刺激是新奇诱导以及神经肽诱导的过度梳理行为的重要潜在机制。
