Koponen H, Stenbäck U, Mattila E, Reinikainen K, Soininen H, Riekkinen P J
Department of Neurology, University Central Hospital of Kuopio, Finland.
Psychol Med. 1989 Aug;19(3):605-9. doi: 10.1017/s003329170002420x.
Cerebrospinal fluid somatostatin-like immunoreactivity (CSF SLI) was determined for 67 elderly patients who met the DSM-III criteria for delirium and for 19 age-matched controls. As a group, and also when subdivided according to the type of delirium, severity of cognitive decline or the type of central nervous system disease, the delirious patients showed significant reductions of SLI compared with the controls, together with a declining trend associated with increasing cognitive dysfunction. These findings are in accordance with previous observations that reduced CSF SLI is associated with diseases in which cognitive function is disturbed and they extend this finding to delirium.
对67名符合精神错乱的《精神疾病诊断与统计手册》第三版标准的老年患者和19名年龄匹配的对照者进行了脑脊液生长抑素样免疫反应性（CSF SLI）测定。作为一个整体，以及根据精神错乱的类型、认知能力下降的严重程度或中枢神经系统疾病的类型进行细分时，与对照组相比，精神错乱患者的SLI显著降低，同时随着认知功能障碍的增加呈下降趋势。这些发现与之前的观察结果一致，即脑脊液SLI降低与认知功能受到干扰的疾病有关，并且将这一发现扩展到了精神错乱。
