Koponen H J, Leinonen E, Lepola U, Riekkinen P J
Moisio Hospital, Mikkeli, Finland.
Acta Psychiatr Scand. 1994 May;89(5):329-34. doi: 10.1111/j.1600-0447.1994.tb01524.x.
Cerebrospinal fluid somatostatin-like immunoreactivity (CSF SLI) was determined for elderly delirious patients during the acute stage and after 1- and 4-year follow-up periods, and the SLI levels were compared with age-equivalent controls. As a whole group, and also when the group was subdivided according to the severity of cognitive decline at the acute stage, type of delirium or the central nervous system disease, delirious patients showed significant reduction of SLI as compared with the controls. In the follow-up, we observed a further reduction of CSF SLI together with significant correlations in the second, third and fourth samples between SLI levels and Mini-Mental State Examination scores. Our results suggest a role for somatostatinergic dysfunction in the genesis of some symptoms of delirium, and this dysfunction may be linked to the long-term prognosis of delirious patients.
对老年谵妄患者在急性期、1年随访期和4年随访期后测定脑脊液生长抑素样免疫反应性（CSF SLI），并将SLI水平与年龄匹配的对照组进行比较。作为一个整体组，以及根据急性期认知衰退的严重程度、谵妄类型或中枢神经系统疾病对该组进行细分时，谵妄患者的SLI与对照组相比均显著降低。在随访中，我们观察到CSF SLI进一步降低，并且在第二、第三和第四个样本中，SLI水平与简易精神状态检查评分之间存在显著相关性。我们的结果表明，生长抑素能功能障碍在谵妄某些症状的发生中起作用，并且这种功能障碍可能与谵妄患者的长期预后有关。
