Koponen H J, Lepola U, Leinonen E
Moisio Hospital, Mikkeli, Finland.
Eur Arch Psychiatry Clin Neurosci. 1994;244(3):131-4. doi: 10.1007/BF02191886.
Cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA) was determined for elderly delirious patients during the acute stage and after a 1-year follow-up period, and the 5-HIAA levels were compared with age-equivalent controls. As compared with the controls, the 5-HIAA levels were significantly higher at the beginning of the index admission in patients with multi-infarct dementia and patients with no apparent CNS disease. The 5-HIAA levels were also higher in the latter subgroup in the 1-year sampling, but no other differences between delirious patients and controls were observed. The one-way procedure showed no differences between the subgroup means of delirious patients when divided according to the severity of cognitive decline or type of delirium in any of the samples. The 5-HIAA levels measured during the index admission correlated with the length of life after delirium suggesting that serotonergic dysfunction may have prognostic significance in delirious patients.
在急性期和1年随访期后，对老年谵妄患者测定脑脊液5-羟吲哚乙酸（CSF 5-HIAA），并将5-HIAA水平与年龄匹配的对照组进行比较。与对照组相比，多梗死性痴呆患者和无明显中枢神经系统疾病的患者在首次入院时5-HIAA水平显著更高。在1年取样时，后一亚组的5-HIAA水平也更高，但未观察到谵妄患者与对照组之间的其他差异。单向程序显示，在任何样本中，根据认知衰退的严重程度或谵妄类型划分的谵妄患者亚组均值之间没有差异。首次入院时测定的5-HIAA水平与谵妄后的寿命长度相关，提示5-羟色胺能功能障碍在谵妄患者中可能具有预后意义。
