González-Tapia David, Velázquez-Zamora Dulce A, Olvera-Cortés María Esther, González-Burgos Ignacio
Laboratorio de Psicobiología, División de Neurociencias, CIBO, IMSS, Guadalajara, Jal, México.
Universidad Politécnica de la Zona Metropolitana de Guadalajara, Guadalajara, Jal, México.
Restor Neurol Neurosci. 2015;33(5):639-45. doi: 10.3233/RNN-140462.
The presynaptic stimulatory activity of parallel fibers on the dendritic spines of cerebellar Purkinje cells (PC) has a strong influence on the organization of motor learning. Motor learning has been shown to modify the synapses established on PC dendritic spines but the plastic changes of the different spine types, possibly underlying motor learning, have not been studied.
Adult male Sprague-Dawley rats were trained daily for 26 days using an acrobatic paradigm (AC), at the end of which dendritic spine density and the proportion of the different types of spines was assessed.
The learning curves of AC rats reflected a robust decrease in the latency for resolution and in the errors committed during the first week of training, which subsequently stabilized until the end of training. Dendritic spine density was greater in these AC rats, reflected in a larger proportion of thin, mushroom and stubby spines.
Since thin spines are associated with acquiring novel information whilst mushroom spines are associated with long-term information storage, there appears to be a strong relationship between AC motor learning and consolidation. The increase in stubby spines could be related to the regulation of excitatory stimulation underlying motor overactivity.
平行纤维对小脑浦肯野细胞（PC）树突棘的突触前刺激活动对运动学习的组织有强烈影响。运动学习已被证明会改变在PC树突棘上建立的突触，但尚未研究可能是运动学习基础的不同棘突类型的可塑性变化。
成年雄性Sprague-Dawley大鼠每天使用杂技范式（AC）训练26天，训练结束时评估树突棘密度和不同类型棘突的比例。
AC大鼠的学习曲线反映出在训练的第一周解决潜伏期和所犯错误显著减少，随后稳定直至训练结束。这些AC大鼠的树突棘密度更大，表现为薄棘、蘑菇棘和短粗棘的比例更高。
由于薄棘与获取新信息相关，而蘑菇棘与长期信息存储相关，AC运动学习与巩固之间似乎存在密切关系。短粗棘的增加可能与运动过度活跃背后的兴奋性刺激调节有关。
