Department of Laboratory Medicine, Wan Fang Hospital.
Jpn J Infect Dis. 2015;68(4):312-7. doi: 10.7883/yoken.JJID.2014.263. Epub 2015 Feb 13.
Herein, we determined the seroprevalence, seroconversion, and risk factors associated with Toxoplasma gondii (T. gondii) infection among pregnant women in Taipei, Taiwan. Pregnant women attending antenatal consultation in a Taipei medical center were invited, and 104 women completed a self-administered structured questionnaire. Venous blood samples were collected during the first and third trimester after consent was obtained. Serum IgG and IgM antibodies (Abs) as well as IgG avidity were analyzed using an enzyme-linked fluorescent assay. Of the samples collected in the first trimester, seven were seropositive for IgG Abs and one was seropositive for IgG + IgM Abs with a borderline avidity index, resulting in an overall seroprevalence of 7.7%. No statistically significant association was found between toxoplasmosis and age, pregnancy history, or any risk factors. Seroconversion was not detected from paired sera between the first and third trimesters. Pregnant women with senior high school education level or those who claimed to knowing Toxoplasma exhibited a significantly higher seroprevalence than those with bachelor degree (P = 0.05) or those who claimed not to have this knowledge (P = 0.05). Therefore, failure to understand the importance of T. gondii infection and the prevention measures resulted in the development of toxoplasmosis among these women.
本研究旨在调查中国台湾省台北市孕妇弓形体（Toxoplasma gondii，T. gondii）感染的血清流行率、血清转化率及相关危险因素。我们邀请了台北某医疗中心产前咨询的孕妇参与研究，并对 104 名孕妇进行了自我管理的结构化问卷调查。征得同意后，在孕妇妊娠的第一和第三孕期分别采集静脉血样本。采用酶联荧光分析法检测血清 IgG 和 IgM 抗体及 IgG 亲和力。在第一孕期采集的样本中，7 份 IgG Ab 血清学阳性，1 份 IgG + IgM Ab 血清学阳性且 IgG 亲和力临界，总血清流行率为 7.7%。未发现弓形虫病与年龄、妊娠史或任何危险因素之间存在统计学关联。未从第一和第三孕期的配对血清中检测到血清转化率。与具有学士学位或声称不了解弓形体的孕妇相比，具有高中文化程度或声称了解弓形体的孕妇的血清流行率显著更高（P=0.05）。因此，这些孕妇对 T. gondii 感染的重要性及其预防措施缺乏了解，导致了弓形体病的发生。
