Akinbami A A, Adewunmi A A, Rabiu K A, Wright K O, Dosunmu A O, Dada M O, Adeyemo T A
Department of Haematology and Blood Transfusion, Lagos State University College of Medicine.
Niger Postgrad Med J. 2010 Jun;17(2):164-7.
Toxoplasma gondii (T.gondii), an obligate intracellular parasite found in many species throughout the world, causes a variety of clinical syndromes in humans and animals. It is also associated with morbidity and mortality in pregnancy. Hence the need to determine the seroprevalence of antibody to toxoplasmosis gondii amongst pregnant women.
A cross- sectional study was carried out using patients attending the ante-natal clinic of Lagos State University Teaching Hospital Ikeja. All consenting newly registered ante-natal patients were recruited consecutively into the study within a time frame of six weeks during which a total of 179 pregnant participants were recruited. Literate participants filled self administered questionnaires whilst the non-literate participants were interviewed by research assistants. Five milliliters of blood was collected from each participant after obtaining patient's consent. Sera were assayed for antitoxoplasmosis IgG antibody by enzyme linked immunosorbent assay. (ELISA.)
A total of 179 pregnant women were studied. Almost 50.8% were between the ages of 25-30 years, 70.8% of the patients studied, had tertiary education. An assessment of the patients' status to anti-toxoplasmosis IgG showed 40.8% were positive while 59.2% were negative. Pet-keeping was a practice amongst only 6.1% of patients whilst 90.5% did not keep pets. Out of those who kept pets, 63.6% were positive while 39.5% were negative. Amongst those who did not keep pets, 39.5% were positive while 60.5% were negative. This difference was not statistically significant. (P=0.261)
It appears that seroprevalence of toxoplasmosis IgG antibody amongst the pregnant women in this study population is high. Therefore, it is valuable to follow up the IgMantibody status of their off springs as its presence indicates recent exposure.
刚地弓形虫是一种专性细胞内寄生虫，在世界各地的许多物种中都有发现，可导致人类和动物出现多种临床综合征。它还与妊娠期间的发病率和死亡率有关。因此，有必要确定孕妇中抗刚地弓形虫抗体的血清流行率。
采用拉各斯州立大学教学医院伊凯贾产前诊所的患者进行横断面研究。在六周的时间内，所有同意参与的新登记产前患者被连续纳入研究，在此期间共招募了179名孕妇参与者。识字的参与者填写自行管理的问卷，而不识字的参与者由研究助理进行访谈。在获得患者同意后，从每位参与者采集5毫升血液。通过酶联免疫吸附测定法（ELISA）检测血清中的抗弓形虫IgG抗体。
共研究了179名孕妇。近50.8%的孕妇年龄在25至30岁之间，70.8%的研究患者拥有高等教育学历。对患者抗弓形虫IgG状态的评估显示，40.8%为阳性，59.2%为阴性。只有6.1%的患者有养宠物的习惯，而90.5%的患者没有养宠物。在养宠物的患者中，63.6%为阳性，39.5%为阴性。在不养宠物的患者中，39.5%为阳性，60.5%为阴性。这种差异无统计学意义（P = 0.261）。
在该研究人群的孕妇中，弓形虫IgG抗体的血清流行率似乎较高。因此，追踪其后代的IgM抗体状态很有价值，因为IgM抗体的存在表明近期有感染。
