Department of Medicine, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
Med Princ Pract. 2015;24(3):250-6. doi: 10.1159/000375304. Epub 2015 Feb 26.
We aimed to assess the efficacy of short-term oral vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes.
This prospective, placebo-controlled trial included 112 type 2 diabetic patients with diabetic peripheral neuropathy (DPN) and vitamin D [25(OH)D] deficiency. Patients were sequentially assigned to a treatment group (n = 57) and a placebo group (n = 55). DPN was assessed using a neuropathy symptom score (NSS), a neuropathy disability score (NDS) and a nerve conduction study (NCS). Vitamin D status was determined by measuring the serum total 25(OH)D concentration. Patients received either oral vitamin D3 capsules or starch capsules once weekly for 8 weeks. The primary outcome was changes in NSS and NDS from baseline. The secondary outcome was changes in the NCS result.
Serum 25(OH)D concentrations significantly improved after oral vitamin D supplementation in the treatment group when compared to the placebo group (32.8 ± 23.7 vs. 1.1 ± 3.6, p < 0.0001). Similarly, the improvement in NSS values was significantly greater in the treatment group than in the placebo group (-1.49 ± 1.37 vs. -0.20 ± 0.59, p < 0.001). No improvement was observed for NDS and NCS between the 2 groups after treatment.
Short-term oral vitamin D3 supplementation improved vitamin D status and the symptoms of neuropathy in patients with type 2 diabetes.
评估短期口服维生素 D 补充对 2 型糖尿病患者周围神经病变的疗效。
本前瞻性、安慰剂对照试验纳入了 112 例伴有维生素 D [25(OH)D]缺乏的 2 型糖尿病周围神经病变（DPN）患者。患者依次被分配至治疗组（n = 57）和安慰剂组（n = 55）。采用神经病变症状评分（NSS）、神经病变残疾评分（NDS）和神经传导研究（NCS）评估 DPN。通过测量血清总 25(OH)D 浓度来确定维生素 D 状态。患者每周接受一次口服维生素 D3 胶囊或淀粉胶囊治疗，共 8 周。主要结局为 NSS 和 NDS 自基线的变化。次要结局为 NCS 结果的变化。
与安慰剂组相比，治疗组口服维生素 D 补充后血清 25(OH)D 浓度显著改善（32.8 ± 23.7 比 1.1 ± 3.6，p < 0.0001）。同样，治疗组 NSS 值的改善明显大于安慰剂组（-1.49 ± 1.37 比 -0.20 ± 0.59，p < 0.001）。治疗后两组 NDS 和 NCS 均无改善。
短期口服维生素 D3 补充可改善 2 型糖尿病患者的维生素 D 状态和神经病变症状。
